Wound healing is a multistep process with four overlapping but distinct stages: hemostasis,
inflammation, proliferation, and remodeling. An alteration at any stage may lead to the …

Address reprint requests to Barrett J. Rollins, MD, PhD, Dana-kines than humans (for
example, there is no clear-cut murine Farber Cancer Institute, 44 Binney St, Boston, MA …

Vascular endothelial growth factor (VEGF) is a secreted mitogen highly specific for cultured
endothelial cells. In vivo VEGF induces microvascular permeability and plays a central role …

Tumor heterogeneity is a hallmark of cancer and one of the primary causes of resistance to
therapies. Triple-negative breast cancer (TNBC), which accounts for 15–20% of all breast …

The chemokines CXCL9/Mig, CXCL10/IP-10, and CXCL11/I-TAC regulate lymphocyte
chemotaxis, mediate vascular pericyte proliferation, and act as angiostatic agents, thus …

Beyond an eminent role in hemostasis and thrombosis, platelets are characterized by expert
functions in assisting and modulating inflammatory reactions and immune responses. This is …

Chemokines, or chemotactic cytokines, and their receptors have been discovered as
essential and selective mediators in leukocyte migration to inflammatory sites and to …

A variety of factors have been identified that regulate angiogenesis, including the CXC
chemokine family. The CXC chemokines are a unique family of cytokines for their ability to …

Chemokines are small proteins that control cellular migration. An extensive family of these
molecules has been described in mammals containing nearly 50 members. Within this …

Neovascularization of ischemic muscle may be sufficient to preserve tissue integrity and/or
function and may thus be considered to be therapeutic. The regulatory role of vascular …