Patch-seq: Past, present, and future

M Lipovsek, C Bardy, CR Cadwell… - Journal of …, 2021 - Soc Neuroscience
Single-cell transcriptomic approaches are revolutionizing neuroscience. Integrating this
wealth of data with morphology and physiology, for the comprehensive study of neuronal …

The nonhuman primate neuroimaging and neuroanatomy project

T Hayashi, Y Hou, MF Glasser, JA Autio, K Knoblauch… - Neuroimage, 2021 - Elsevier
Multi-modal neuroimaging projects such as the Human Connectome Project (HCP) and UK
Biobank are advancing our understanding of human brain architecture, function …

Comparative cellular analysis of motor cortex in human, marmoset and mouse

TE Bakken, NL Jorstad, Q Hu, BB Lake, W Tian… - Nature, 2021 - nature.com
The primary motor cortex (M1) is essential for voluntary fine-motor control and is functionally
conserved across mammals. Here, using high-throughput transcriptomic and epigenomic …

A multimodal cell census and atlas of the mammalian primary motor cortex

Principal manuscript editors, Analysis coordination… - Nature, 2021 - nature.com
Here we report the generation of a multimodal cell census and atlas of the mammalian
primary motor cortex as the initial product of the BRAIN Initiative Cell Census Network …

Local connectivity and synaptic dynamics in mouse and human neocortex

L Campagnola, SC Seeman, T Chartrand, L Kim… - Science, 2022 - science.org
We present a unique, extensive, and open synaptic physiology analysis platform and
dataset. Through its application, we reveal principles that relate cell type to synaptic …

Signature morpho-electric, transcriptomic, and dendritic properties of human layer 5 neocortical pyramidal neurons

BE Kalmbach, RD Hodge, NL Jorstad, S Owen… - Neuron, 2021 - cell.com
In the neocortex, subcerebral axonal projections originate largely from layer 5 (L5)
extratelencephalic-projecting (ET) neurons. The unique morpho-electric properties of these …

[HTML][HTML] Linking transcriptomes with morphological and functional phenotypes in mammalian retinal ganglion cells

W Huang, Q Xu, J Su, L Tang, ZZ Hao, C Xu, R Liu… - Cell Reports, 2022 - cell.com
Retinal ganglion cells (RGCs) are the brain's gateway to the visual world. They can be
classified into different types on the basis of their electrophysiological, transcriptomic, or …

Cortical hierarchy, dual counterstream architecture and the importance of top-down generative networks

J Vezoli, L Magrou, R Goebel, XJ Wang, K Knoblauch… - Neuroimage, 2021 - Elsevier
Hierarchy is a major organizational principle of the cortex and underscores modern
computational theories of cortical function. The local microcircuit amplifies long-distance …

Evolution of cellular diversity in primary motor cortex of human, marmoset monkey, and mouse

TE Bakken, NL Jorstad, Q Hu, BB Lake, W Tian… - BioRxiv, 2020 - biorxiv.org
The primary motor cortex (M1) is essential for voluntary fine motor control and is functionally
conserved across mammals. Using high-throughput transcriptomic and epigenomic profiling …

Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences

H Moradi Chameh, S Rich, L Wang, FD Chen… - Nature …, 2021 - nature.com
In the human neocortex coherent interlaminar theta oscillations are driven by deep cortical
layers, suggesting neurons in these layers exhibit distinct electrophysiological properties. To …