TSPO in diverse CNS pathologies and psychiatric disease: A critical review and a way forward
TR Guilarte - Pharmacology & therapeutics, 2019 - Elsevier
Abstract The use of Translocator Protein 18 kDa (TSPO) as a clinical neuroimaging
biomarker of brain injury and neuroinflammation has increased exponentially in the last …
biomarker of brain injury and neuroinflammation has increased exponentially in the last …
Disorders in the initial steps of steroid hormone synthesis
WL Miller - The Journal of steroid biochemistry and molecular …, 2017 - Elsevier
Steroidogenesis begins with cellular internalization of low-density lipoprotein particles and
subsequent intracellular processing of cholesterol. Disorders in these steps include …
subsequent intracellular processing of cholesterol. Disorders in these steps include …
Neuronal activity increases translocator protein (TSPO) levels
The mitochondrial protein, translocator protein (TSPO), is a widely used biomarker of
neuroinflammation, but its non-selective cellular expression pattern implies roles beyond …
neuroinflammation, but its non-selective cellular expression pattern implies roles beyond …
Translational evaluation of translocator protein as a marker of neuroinflammation in schizophrenia
T Notter, JM Coughlin, T Gschwind… - Molecular …, 2018 - nature.com
Positron emission tomography (PET) imaging with radiotracers that target translocator
protein 18 kDa (TSPO) has become a popular approach to assess putative …
protein 18 kDa (TSPO) has become a popular approach to assess putative …
Long-term diazepam treatment enhances microglial spine engulfment and impairs cognitive performance via the mitochondrial 18 kDa translocator protein (TSPO)
Y Shi, M Cui, K Ochs, M Brendel, FL Strübing… - Nature …, 2022 - nature.com
Benzodiazepines are widely administered drugs to treat anxiety and insomnia. In addition to
tolerance development and abuse liability, their chronic use may cause cognitive …
tolerance development and abuse liability, their chronic use may cause cognitive …
Reconceptualization of translocator protein as a biomarker of neuroinflammation in psychiatry
T Notter, JM Coughlin, A Sawa, U Meyer - Molecular psychiatry, 2018 - nature.com
A great deal of interest in psychiatric research is currently centered upon the pathogenic role
of inflammatory processes. Positron emission tomography (PET) using radiolabeled ligands …
of inflammatory processes. Positron emission tomography (PET) using radiolabeled ligands …
Gene expression studies in Depression development and treatment: an overview of the underlying molecular mechanisms and biological processes to identify …
N Mariani, N Cattane, C Pariante, A Cattaneo - Translational psychiatry, 2021 - nature.com
A combination of different risk factors, such as genetic, environmental and psychological
factors, together with immune system, stress response, brain neuroplasticity and the …
factors, together with immune system, stress response, brain neuroplasticity and the …
Neurosteroidogenesis today: novel targets for neuroactive steroid synthesis and action and their relevance for translational research
Neuroactive steroids are endogenous neuromodulators synthesised in the brain that rapidly
alter neuronal excitability by binding to membrane receptors, in addition to the regulation of …
alter neuronal excitability by binding to membrane receptors, in addition to the regulation of …
Cellular sources and regional variations in the expression of the neuroinflammatory marker translocator protein (TSPO) in the normal brain
C Betlazar, M Harrison-Brown, RJ Middleton… - International Journal of …, 2018 - mdpi.com
The inducible expression of the mitochondrial translocator protein 18 kDa (TSPO) by
activated microglia is a prominent, regular feature of acute and chronic-progressive brain …
activated microglia is a prominent, regular feature of acute and chronic-progressive brain …
Translocator protein 18 kDa (TSPO) deficiency inhibits microglial activation and impairs mitochondrial function
R Yao, R Pan, C Shang, X Li, J Cheng, J Xu… - Frontiers in …, 2020 - frontiersin.org
TSPO is mainly expressed in the mitochondrial outer membrane of microglia in the central
nervous system, and its expression is greatly increased when microglia are activated …
nervous system, and its expression is greatly increased when microglia are activated …