Abstract The use of Translocator Protein 18 kDa (TSPO) as a clinical neuroimaging
biomarker of brain injury and neuroinflammation has increased exponentially in the last …

Steroidogenesis begins with cellular internalization of low-density lipoprotein particles and
subsequent intracellular processing of cholesterol. Disorders in these steps include …

The mitochondrial protein, translocator protein (TSPO), is a widely used biomarker of
neuroinflammation, but its non-selective cellular expression pattern implies roles beyond …

Positron emission tomography (PET) imaging with radiotracers that target translocator
protein 18 kDa (TSPO) has become a popular approach to assess putative …

Benzodiazepines are widely administered drugs to treat anxiety and insomnia. In addition to
tolerance development and abuse liability, their chronic use may cause cognitive …

A great deal of interest in psychiatric research is currently centered upon the pathogenic role
of inflammatory processes. Positron emission tomography (PET) using radiolabeled ligands …

A combination of different risk factors, such as genetic, environmental and psychological
factors, together with immune system, stress response, brain neuroplasticity and the …

Neuroactive steroids are endogenous neuromodulators synthesised in the brain that rapidly
alter neuronal excitability by binding to membrane receptors, in addition to the regulation of …

The inducible expression of the mitochondrial translocator protein 18 kDa (TSPO) by
activated microglia is a prominent, regular feature of acute and chronic-progressive brain …

TSPO is mainly expressed in the mitochondrial outer membrane of microglia in the central
nervous system, and its expression is greatly increased when microglia are activated …