Nucleosides for the treatment of respiratory RNA virus infections
PC Jordan, SK Stevens, J Deval - Antiviral Chemistry and …, 2018 - journals.sagepub.com
Influenza virus, respiratory syncytial virus, human metapneumovirus, parainfluenza virus,
coronaviruses, and rhinoviruses are among the most common viruses causing mild …
coronaviruses, and rhinoviruses are among the most common viruses causing mild …
Coronavirus accessory protein ORF3 biology and its contribution to viral behavior and pathogenesis
Coronavirus porcine epidemic diarrhea virus (PEDV) is classified in the genus
Alphacoronavirus, family Coronaviridae that encodes the only accessory protein, ORF3 …
Alphacoronavirus, family Coronaviridae that encodes the only accessory protein, ORF3 …
Structure of the respiratory syncytial virus polymerase complex
MSA Gilman, C Liu, A Fung, I Behera, P Jordan… - Cell, 2019 - cell.com
Numerous interventions are in clinical development for respiratory syncytial virus (RSV)
infection, including small molecules that target viral transcription and replication. These …
infection, including small molecules that target viral transcription and replication. These …
Minimal Elements Required for the Formation of Respiratory Syncytial Virus Cytoplasmic Inclusion Bodies In Vivo and In Vitro
M Galloux, J Risso-Ballester, CA Richard, J Fix… - MBio, 2020 - Am Soc Microbiol
Infection of host cells by the respiratory syncytial virus (RSV) is characterized by the
formation of spherical cytoplasmic inclusion bodies (IBs). These structures, which …
formation of spherical cytoplasmic inclusion bodies (IBs). These structures, which …
Cryo-EM structure of the respiratory syncytial virus RNA polymerase
The respiratory syncytial virus (RSV) RNA polymerase, constituted of a 250 kDa large (L)
protein and tetrameric phosphoprotein (P), catalyzes three distinct enzymatic activities …
protein and tetrameric phosphoprotein (P), catalyzes three distinct enzymatic activities …
[HTML][HTML] RSV hijacks cellular protein phosphatase 1 to regulate M2-1 phosphorylation and viral transcription
CA Richard, V Rincheval, S Lassoued, J Fix… - PLoS …, 2018 - journals.plos.org
Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs)
in which all the components of the viral RNA polymerase are concentrated. In this work, we …
in which all the components of the viral RNA polymerase are concentrated. In this work, we …
An ultraweak interaction in the intrinsically disordered replication machinery is essential for measles virus function
S Milles, MR Jensen, C Lazert, S Guseva… - Science …, 2018 - science.org
Measles virus genome encapsidation is essential for viral replication and is controlled by the
intrinsically disordered phosphoprotein (P) maintaining the nucleoprotein in a monomeric …
intrinsically disordered phosphoprotein (P) maintaining the nucleoprotein in a monomeric …
Structural modeling, energetic analysis and molecular design of a π-stacking system at the complex interface of pediatric respiratory syncytial virus nucleocapsid with …
H Liu, L Shen, C Pan, W Huang - Biophysical Chemistry, 2023 - Elsevier
Human respiratory syncytial virus (RSV) is a primary cause of lower respiratory tract
infections and hospital visits during infancy and childhood. The RSV phosphoprotein (P) is a …
infections and hospital visits during infancy and childhood. The RSV phosphoprotein (P) is a …
Tetramerization of phosphoprotein is essential for respiratory syncytial virus budding while its n-terminal region mediates direct interactions with the matrix protein
M Bajorek, M Galloux, CA Richard, O Szekely… - Journal of …, 2021 - Am Soc Microbiol
It was shown previously that the matrix (M), phosphoprotein (P), and fusion (F) proteins of
respiratory syncytial virus (RSV) are sufficient to produce virus-like particles (VLPs) that …
respiratory syncytial virus (RSV) are sufficient to produce virus-like particles (VLPs) that …
Respiratory syncytial virus NS1 protein targets the transactivator binding domain of MED25
J Dong, V Basse, M Bierre, AP de Oliveira… - Journal of Molecular …, 2022 - Elsevier
Human RSV is the leading cause of infantile bronchiolitis in the world and one of the major
causes of childhood deaths in resource-poor settings. It is a major unmet target for vaccines …
causes of childhood deaths in resource-poor settings. It is a major unmet target for vaccines …