Nucleosides for the treatment of respiratory RNA virus infections

PC Jordan, SK Stevens, J Deval - Antiviral Chemistry and …, 2018 - journals.sagepub.com
Influenza virus, respiratory syncytial virus, human metapneumovirus, parainfluenza virus,
coronaviruses, and rhinoviruses are among the most common viruses causing mild …

Coronavirus accessory protein ORF3 biology and its contribution to viral behavior and pathogenesis

F Si, S Song, R Yu, Z Li, W Wei, C Wu - Iscience, 2023 - cell.com
Coronavirus porcine epidemic diarrhea virus (PEDV) is classified in the genus
Alphacoronavirus, family Coronaviridae that encodes the only accessory protein, ORF3 …

Structure of the respiratory syncytial virus polymerase complex

MSA Gilman, C Liu, A Fung, I Behera, P Jordan… - Cell, 2019 - cell.com
Numerous interventions are in clinical development for respiratory syncytial virus (RSV)
infection, including small molecules that target viral transcription and replication. These …

Minimal Elements Required for the Formation of Respiratory Syncytial Virus Cytoplasmic Inclusion Bodies In Vivo and In Vitro

M Galloux, J Risso-Ballester, CA Richard, J Fix… - MBio, 2020 - Am Soc Microbiol
Infection of host cells by the respiratory syncytial virus (RSV) is characterized by the
formation of spherical cytoplasmic inclusion bodies (IBs). These structures, which …

Cryo-EM structure of the respiratory syncytial virus RNA polymerase

D Cao, Y Gao, C Roesler, S Rice, P D'Cunha… - Nature …, 2020 - nature.com
The respiratory syncytial virus (RSV) RNA polymerase, constituted of a 250 kDa large (L)
protein and tetrameric phosphoprotein (P), catalyzes three distinct enzymatic activities …

[HTML][HTML] RSV hijacks cellular protein phosphatase 1 to regulate M2-1 phosphorylation and viral transcription

CA Richard, V Rincheval, S Lassoued, J Fix… - PLoS …, 2018 - journals.plos.org
Respiratory syncytial virus (RSV) RNA synthesis occurs in cytoplasmic inclusion bodies (IBs)
in which all the components of the viral RNA polymerase are concentrated. In this work, we …

An ultraweak interaction in the intrinsically disordered replication machinery is essential for measles virus function

S Milles, MR Jensen, C Lazert, S Guseva… - Science …, 2018 - science.org
Measles virus genome encapsidation is essential for viral replication and is controlled by the
intrinsically disordered phosphoprotein (P) maintaining the nucleoprotein in a monomeric …

Structural modeling, energetic analysis and molecular design of a π-stacking system at the complex interface of pediatric respiratory syncytial virus nucleocapsid with …

H Liu, L Shen, C Pan, W Huang - Biophysical Chemistry, 2023 - Elsevier
Human respiratory syncytial virus (RSV) is a primary cause of lower respiratory tract
infections and hospital visits during infancy and childhood. The RSV phosphoprotein (P) is a …

Tetramerization of phosphoprotein is essential for respiratory syncytial virus budding while its n-terminal region mediates direct interactions with the matrix protein

M Bajorek, M Galloux, CA Richard, O Szekely… - Journal of …, 2021 - Am Soc Microbiol
It was shown previously that the matrix (M), phosphoprotein (P), and fusion (F) proteins of
respiratory syncytial virus (RSV) are sufficient to produce virus-like particles (VLPs) that …

Respiratory syncytial virus NS1 protein targets the transactivator binding domain of MED25

J Dong, V Basse, M Bierre, AP de Oliveira… - Journal of Molecular …, 2022 - Elsevier
Human RSV is the leading cause of infantile bronchiolitis in the world and one of the major
causes of childhood deaths in resource-poor settings. It is a major unmet target for vaccines …