Safety of folic acid
There is a large body of literature demonstrating the efficacy of maternal folic acid intake in
preventing birth defects, as well as investigations into potential adverse consequences of …
preventing birth defects, as well as investigations into potential adverse consequences of …
Cell cycle regulation of folate‐mediated one‐carbon metabolism
Folate‐mediated one‐carbon metabolism (FOCM) comprises a network of interconnected
folate‐dependent metabolic pathways responsible for serine and glycine interconversion, de …
folate‐dependent metabolic pathways responsible for serine and glycine interconversion, de …
Methionine synthase is essential for cancer cell proliferation in physiological folate environments
Folate metabolism can be an effective target for cancer treatment. However, standard cell
culture conditions utilize folic acid, a non-physiological folate source for most tissues. We …
culture conditions utilize folic acid, a non-physiological folate source for most tissues. We …
Nuclear folate metabolism
MS Field, E Kamynina, J Chon… - Annual review of …, 2018 - annualreviews.org
Despite unequivocal evidence that folate deficiency increases risk for human pathologies,
and that folic acid intake among women of childbearing age markedly decreases risk for …
and that folic acid intake among women of childbearing age markedly decreases risk for …
Pro‐con debate: nitrous oxide for labor analgesia
MC Vallejo, MI Zakowski - BioMed Research International, 2019 - Wiley Online Library
This Pro‐Con debate will provide the practitioner with an evidence‐based knowledge
approach to assist the clinician in determining whether to employ (Pro) or not to employ …
approach to assist the clinician in determining whether to employ (Pro) or not to employ …
A QSP model of prostate cancer immunotherapy to identify effective combination therapies
Immunotherapy, by enhancing the endogenous anti-tumor immune responses, is showing
promising results for the treatment of numerous cancers refractory to conventional therapies …
promising results for the treatment of numerous cancers refractory to conventional therapies …
Effect of greenhouse gases on human health
S Naiyer, SS Abbas - Greenhouse Gases: Sources, Sinks and Mitigation, 2022 - Springer
Greenhouse gases (GHGs) are the essential component for our planet earth to maintain an
ambient condition for our survival. These gases in collaboration form an atmospheric layer …
ambient condition for our survival. These gases in collaboration form an atmospheric layer …
Dihydrofolate reductase inhibition effect of 5-substituted pyrido [2, 3-d] pyrimidines: Synthesis, antitumor activity and molecular modeling study
A new series of pyrido [2, 3-d] pyrimidines 3–18 bearing substitution at C-5 position was
synthesized. All compounds were tested for their in vitro antitumor activity against five …
synthesized. All compounds were tested for their in vitro antitumor activity against five …
Stochastic simulation algorithms for computational systems biology: Exact, approximate, and hybrid methods
Nowadays, mathematical modeling is playing a key role in many different research fields. In
the context of system biology, mathematical models and their associated computer …
the context of system biology, mathematical models and their associated computer …
Human dihydrofolate reductase inhibition effect of 1-Phenylpyrazolo [3, 4–d] pyrimidines: synthesis, antitumor evaluation and molecular modeling study
IM Salem, SM Mostafa, I Salama, OI El-Sabbagh… - Bioorganic …, 2022 - Elsevier
A new series of pyrazolo [3, 4–d] pyrimidine analogues bearing different amino acid
conjugates 10 am were synthesized with the aim to evaluate their antitumor effect through …
conjugates 10 am were synthesized with the aim to evaluate their antitumor effect through …