Astrocyte endfeet in brain function and pathology: open questions

B Díaz-Castro, S Robel, A Mishra - Annual Review of …, 2023 - annualreviews.org
Astrocyte endfeet enwrap the entire vascular tree within the central nervous system, where
they perform important functions in regulating the blood-brain barrier (BBB), cerebral blood …

Physiology of astroglia

A Verkhratsky, M Nedergaard - Physiological reviews, 2018 - journals.physiology.org
Astrocytes are neural cells of ectodermal, neuroepithelial origin that provide for homeostasis
and defense of the central nervous system (CNS). Astrocytes are highly heterogeneous in …

Astrocytes in chronic pain and itch

RR Ji, CR Donnelly, M Nedergaard - Nature Reviews Neuroscience, 2019 - nature.com
Astrocytes are critical for maintaining the homeostasis of the CNS. Increasing evidence
suggests that a number of neurological and neuropsychiatric disorders, including chronic …

[HTML][HTML] Behaviorally consequential astrocytic regulation of neural circuits

J Nagai, X Yu, T Papouin, E Cheong, MR Freeman… - Neuron, 2021 - cell.com
Astrocytes are a large and diverse population of morphologically complex cells that exist
throughout nervous systems of multiple species. Progress over the last two decades has …

[HTML][HTML] Cell biology of astrocyte-synapse interactions

NJ Allen, C Eroglu - Neuron, 2017 - cell.com
Astrocytes, the most abundant glial cells in the mammalian brain, are critical regulators of
brain development and physiology through dynamic and often bidirectional interactions with …

Neuron–glia interactions in the pathophysiology of epilepsy

DC Patel, BP Tewari, L Chaunsali… - Nature Reviews …, 2019 - nature.com
Epilepsy is a neurological disorder afflicting~ 65 million people worldwide. It is caused by
aberrant synchronized firing of populations of neurons primarily due to imbalance between …

Astroglial Kir4. 1 in the lateral habenula drives neuronal bursts in depression

Y Cui, Y Yang, Z Ni, Y Dong, G Cai, A Foncelle, S Ma… - Nature, 2018 - nature.com
Enhanced bursting activity of neurons in the lateral habenula (LHb) is essential in driving
depression-like behaviours, but the cause of this increase has been unknown. Here, using a …

Astrocyte-immune cell interactions in physiology and pathology

RT Han, RD Kim, AV Molofsky, SA Liddelow - Immunity, 2021 - cell.com
Astrocytes play both physiological and pathological roles in maintaining central nervous
system (CNS) function. Here, we review the varied functions of astrocytes and how these …

Differentiation and maturation of oligodendrocytes in human three-dimensional neural cultures

RM Marton, Y Miura, SA Sloan, Q Li, O Revah… - Nature …, 2019 - nature.com
Investigating human oligodendrogenesis and the interaction of oligodendrocytes with
neurons and astrocytes would accelerate our understanding of the mechanisms underlying …

Going the extra (synaptic) mile: excitotoxicity as the road toward neurodegenerative diseases

A Armada-Moreira, JI Gomes, CC Pina… - Frontiers in cellular …, 2020 - frontiersin.org
Excitotoxicity is a phenomenon that describes the toxic actions of excitatory
neurotransmitters, primarily glutamate, where the exacerbated or prolonged activation of …