ATP citrate lyase (ACLY), a strategic metabolic enzyme that catalyzes the glycolytic to lipidic
metabolism, has gained increasing attention as an attractive therapeutic target for …

Chemo‐immunotherapy has shown great success in boosting systemic anti‐tumor effects in
the clinic. However, cancer cells can escape the maximum impact of chemotherapy through …

Abstract Macropinocytosis (MP), the actin-dependent bulk uptake of extracellular fluids,
plays a central role in nutrient scavenging, allowing cancer cells to sustain their growth in …

Objective Mucosal T cells play a major role in inflammatory bowel disease (IBD). However,
their immunometabolism during intestinal inflammation is poorly understood. Due to its …

Fatty acid metabolism can provide various products essential for viral infections. How
vaccinia virus (VACV), the prototype of poxviruses, modulates fatty acid metabolism is not …

Abstract N6-methyladenosine (m 6 A) and lipid metabolism reprogramming play pivotal
roles in cancer development. Nevertheless, the precise functions of m 6 A methyltransferase …

The development of a cytosolic delivery strategy for biopharmaceuticals is one of the central
issues in drug development. Knowledge of the mechanisms underlying these processes …

ATP-citrate lyase (ACLY) is a critical metabolic enzyme and promising target for drug
development. The structure determinations of ACLY have revealed its homotetramer states …

Normal cells grow and divide only when instructed to by signaling pathways stimulated by
exogenous growth factors. A nearly ubiquitous feature of cancer cells is their capacity to …

Proteostasis is a complex network of pathways that act to maintain the balance between
protein synthesis, folding, trafficking, and degradation. It is vital for cells to maintain …