Background Early intravenous administration of tranexamic acid has been shown to protect
the intestinal barrier after a model of trauma-hemorrhagic shock in the rat, but the potential …

Diabetic retinopathy is the most common cause of vision loss among diabetic patients.
Although hyperglycemia produces retinal oxidative stress in long-standing diabetes, the …

Simple Summary Oral squamous cell carcinoma (OSCC) constitutes more than 90% of head
and neck cancers and a high prevalence rate in some parts of the world. Alcohol …

Objectives Revascularization is necessary in patients with ischemic stroke, however it does
not address inflammation that contribute to reperfusion injury and the early growth of …

The standard of care for fluid resuscitation of trauma/hemorrhagic shock (T/HS) is the
infusion of blood. However, in many instances, blood product transfusion may not be …

Introduction The mechanisms underlying the protective effects of atrial natriuretic peptide
(ANP) on the gut barrier during traumatic hemorrhagic shock (THS) remain elusive. This …

The proteasome is a validated target in drug discovery for diseases associated with unusual
proteasomal activity. Here we report that two diphenyldihaloketones, CLEFMA and EF24 …

This study aimed to explore the protective effect of Shenfu on the hemodynamics and gut
integrity in a porcine model of hemorrhagic shock. Hemorrhagic shock was induced in 32 …

Intestinal ischemic-reperfusion injury (IRI) occurs when vascular blood flow is interrupted in
the mesenteric vessels, followed by reperfusion when blood flow is re-established to the …

Selective killing of cancer cells by chemotherapy has been an age old challenge, but certain
unique features of cancer cells allow discriminatory response between cancer and normal …