Since the beginning of history, natural products have been an abundant source of bioactive
molecules for the treatment of different diseases, including cancer. Many allyl derivatives …

Introduction Glycometabolic rearrangements (aerobic glycolysis) is a hallmark of pancreatic
ductal adenocarcinoma (PDAC) and contributes to tumorigenesis and progression through …

Regulatory dependencies in molecular networks are the basis of dynamic behaviors
affecting the phenotypical landscape. With the advance of high throughput technologies, the …

The dynamics of cellular mechanisms can be investigated through the analysis of networks.
One of the simplest but most popular modeling strategies involves logic-based models …

Pancreatic neuroendocrine tumors (PanNETs) are a rare tumor entity with largely
unpredictable progression and increasing incidence in developed countries. Molecular …

Motivation Interaction graphs are able to describe regulatory dependencies between
compounds without capturing dynamics. In contrast, mathematical models that are based on …

As the quality of beef products has received increasing attention, it is essential to explore the
underlying transcriptional and epigenetic mechanisms of meat traits. Our project uses …

Introduction: The actin regulatory protein, cofilin plays a key signaling role in many cells for
numerous cellular responses including in proliferation, development, motility, migration …

Controlling phenotypical landscapes is of vital interest to modern biology. This task becomes
highly demanding because cellular decisions involve complex networks engaging in …

Systems biology investigates the understanding of complex biological processes, such as
ageing or cancer, by integrating a holistic view, which is mostly unconsidered when …