Delirium in elderly people

SK Inouye, RGJ Westendorp, JS Saczynski - The lancet, 2014 - thelancet.com
Delirium is an acute disorder of attention and cognition in elderly people (ie, those aged 65
years or older) that is common, serious, costly, under-recognised, and often fatal. A formal …

Neuropathogenesis of delirium: review of current etiologic theories and common pathways

JR Maldonado - The American Journal of Geriatric Psychiatry, 2013 - Elsevier
Delirium is a neurobehavioral syndrome caused by dysregulation of neuronal activity
secondary to systemic disturbances. Over time, a number of theories have been proposed in …

Sepsis associated encephalopathy

N Chaudhry, AK Duggal - Advances in medicine, 2014 - Wiley Online Library
Sepsis associated encephalopathy (SAE) is a common but poorly understood neurological
complication of sepsis. It is characterized by diffuse brain dysfunction secondary to infection …

[HTML][HTML] Impaired cerebral autoregulation is associated with brain dysfunction in patients with sepsis

IA Crippa, C Subirà, JL Vincent, RF Fernandez… - Critical Care, 2018 - Springer
Background Sepsis-associated brain dysfunction (SABD) is associated with high morbidity
and mortality. The pathophysiology of SABD is multifactorial. One hypothesis is that impaired …

[HTML][HTML] A retrospective study of sepsis-associated encephalopathy: epidemiology, clinical features and adverse outcomes

J Chen, X Shi, M Diao, G Jin, Y Zhu, W Hu… - BMC Emergency Medicine, 2020 - Springer
Background Sepsis-associated encephalopathy (SAE) is a common complication of sepsis
that may result in worse outcomes. This study was designed to determine the epidemiology …

Epidemiological features and risk factors of sepsis-associated encephalopathy in intensive care unit patients: 2008-2011

L Zhang, X Wang, Y Ai, Q Guo, L Huang… - Chinese medical …, 2012 - journals.lww.com
Background Encephalopathy is a common complication of sepsis, and its onset can occur at
any stage of sepsis and implies worse prognosis. However, the incidence, epidemiology …

Delirium

B Setters, LM Solberg - Primary Care: Clinics in Office …, 2017 - primarycare.theclinics.com
Delirium is a common neurocognitive disorder characterized by an acute change in
cognition, attention, and consciousness that results in what experts describe as brain failure …

[HTML][HTML] Pharmacological and nonpharmacological management of delirium in critically ill patients

DM Hipp, EW Ely - Neurotherapeutics, 2012 - Elsevier
Delirium is a common yet under-diagnosed syndrome of acute brain dysfunction, which is
characterized by inattention, fluctuating mental status, altered level of consciousness, or …

Characterization of sepsis and sepsis-associated encephalopathy

Q Feng, YH Ai, H Gong, L Wu, ML Ai… - Journal of intensive …, 2019 - journals.sagepub.com
Background: Sepsis and sepsis-associated encephalopathy (SAE) are common intensive
care unit (ICU) diseases; the morbidity and mortality are high. The present study analyzed …

Matrix metalloproteinase-2 and metalloproteinase-9 activities are associated with blood–brain barrier dysfunction in an animal model of severe sepsis

F Dal-Pizzol, HA Rojas, EM Dos Santos, F Vuolo… - Molecular …, 2013 - Springer
There is no description on the mechanisms associated with blood–brain barrier (BBB)
disruption during sepsis development. Thus, we here determined changes in permeability of …