Interlinked and fundamental aging processes appear to be a root-cause contributor to many
disorders and diseases. One such process is cellular senescence, which entails a state of …

Cellular senescence is a state of stable, terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory, pro-inflammatory phenotype. Entry of cells …

Senescence is a cellular response to a variety of stress signals that is characterized by a
stable withdrawal from the cell cycle and major changes in cell morphology and physiology …

Mass spectrometry-based metabolomics approaches can enable detection and
quantification of many thousands of metabolite features simultaneously. However …

Derailed cytokine and immune cell networks account for the organ damage and the clinical
severity of COVID-19 (refs.,,–). Here we show that SARS-CoV-2, like other viruses, evokes …

Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …

Cellular senescence, first described in vitro in 1961, has become a focus for biotech
companies that target it to ameliorate a variety of human conditions. Eminently characterized …

Cellular senescence is a stress response that elicits a permanent cell cycle arrest and
triggers profound phenotypic changes such as the production of a bioactive secretome …

Cellular senescence entails a state of an essentially irreversible proliferative arrest in which
cells remain metabolically active and secrete a range of pro-inflammatory and proteolytic …

The clinical severity of coronavirus disease 2019 (COVID-19) is largely determined by host
factors. Recent advances point to cellular senescence, an ageing-related switch in cellular …