Heat perception enables acute avoidance responses to prevent tissue damage and
maintain body thermal homeostasis. Unlike other modalities, how heat signals are …

Accumulating evidence has suggested that a great proportion of sepsis survivors suffer from
long-term cognitive impairments after hospital discharge, leading to decreased life quality …

Freezing is a conserved defensive behaviour that constitutes a major stress-coping
mechanism. Decades of research have demonstrated a role of the amygdala …

NR2D subunit-containing NMDA receptors (NMDARs) gradually disappear during brain
maturation but can be recruited by pathophysiological stimuli in the adult brain. Here, we …

Parkinson's disease (PD) is among the most prevalent neurodegenerative diseases, and
approximately one third of patients with PD are estimated to have depression. Paraquat (PQ) …

Depressive symptoms, such as anhedonia, decreased social interaction, and lack of
motivation, implicate brain reward systems in the pathophysiology of depression. Exposure …

Obesity affects more than a third adult population in the United States; the prevalence is
even higher in patients with major depression disorders. GWAS studies identify the receptor …

Background Depression and anxiety disorders are prevalent psychiatric conditions, and
currently utilized chemical drugs typically come with significant adverse effects. China …

Motivation-driven mating is a basic affair for the maintenance of species. However, the
underlying molecular mechanisms that control mating motivation are not fully understood …

Epidemiological and experimental evidence demonstrates that maternal exposure to
infection during gestation increases the offspring's risk of developing schizophrenia and …