Sperm DNA fragmentation testing: Summary evidence and clinical practice recommendations

SC Esteves, A Zini, RM Coward, DP Evenson… - Andrologia, 2021 - Wiley Online Library
We herein summarise the evidence concerning the impact of sperm DNA fragmentation in
various clinical infertility scenarios and the advances on sperm DNA fragmentation tests …

[HTML][HTML] Sperm DNA fragmentation: a new guideline for clinicians

A Agarwal, A Majzoub, S Baskaran… - The world journal of …, 2020 - ncbi.nlm.nih.gov
Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The
spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases …

[HTML][HTML] Clinical utility of sperm DNA fragmentation testing: practice recommendations based on clinical scenarios

A Agarwal, A Majzoub, SC Esteves, E Ko… - Translational …, 2016 - ncbi.nlm.nih.gov
Sperm DNA fragmentation (SDF) has been generally acknowledged as a valuable tool for
male fertility evaluation. While its detrimental implications on sperm function were …

[HTML][HTML] The effect of sperm DNA fragmentation index on assisted reproductive technology outcomes and its relationship with semen parameters and lifestyle

H Yang, G Li, H Jin, Y Guo, Y Sun - Translational andrology and …, 2019 - ncbi.nlm.nih.gov
Background The sperm DNA fragmentation index (DFI) is widely regarded as a key measure
for assessing male fertility, but the predictive value of the DFI for outcomes of assisted …

An update on clinical and surgical interventions to reduce sperm DNA fragmentation in infertile men

SC Esteves, D Santi, M Simoni - Andrology, 2020 - Wiley Online Library
Background Sperm chromatin integrity is essential for normal embryo development and
pregnancy outcome. Sperm DNA fragmentation (SDF) testing constitutes a diagnostic tool to …

[HTML][HTML] Role of sperm DNA fragmentation in male factor infertility: A systematic review

CL Cho, A Agarwal - Arab journal of urology, 2018 - Elsevier
Objective To summarise the latest evidence on the role of sperm DNA fragmentation (SDF)
in male factor infertility, as SDF has been emerging as a valuable tool for male infertility …

[HTML][HTML] The Society for Translational Medicine: clinical practice guidelines for sperm DNA fragmentation testing in male infertility

A Agarwal, CL Cho, A Majzoub… - … andrology and urology, 2017 - ncbi.nlm.nih.gov
Sperm DNA fragmentation (SDF) testing has been emerging as a valuable tool for male
fertility evaluation. While the essential role of sperm DNA integrity in human reproduction …

[HTML][HTML] Utility of antioxidants in the treatment of male infertility: clinical guidelines based on a systematic review and analysis of evidence

A Agarwal, K Leisegang, A Majzoub… - The world journal of …, 2021 - ncbi.nlm.nih.gov
It is widely accepted that oxidative stress plays an important role in the pathophysiology of
male infertility and that antioxidants could have a significant role in the treatment of male …

TUNEL assay—Standardized method for testing sperm DNA fragmentation

R Sharma, C Iovine, A Agarwal, R Henkel - Andrologia, 2021 - Wiley Online Library
Sperm DNA integrity is important for normal functions such as fertilization, implantation,
pregnancy and fetal development. Sperm DNA fragmentation (SDF) is more common in …

[HTML][HTML] Controversy and consensus on the management of elevated sperm DNA fragmentation in male infertility: a global survey, current guidelines, and expert …

A Farkouh, A Agarwal, TAAAM Hamoda… - The world journal of …, 2023 - ncbi.nlm.nih.gov
Purpose Sperm DNA fragmentation (SDF) has been associated with male infertility and poor
outcomes of assisted reproductive technology (ART). The purpose of this study was to …