The discovery of leptin was intrinsically associated with its ability to regulate body weight.
However, the effects of leptin are more far-reaching and include profound glucose-lowering …

Accumulated evidence from genetic animal models suggests that the brain, particularly the
hypothalamus, has a key role in the homeostatic regulation of energy and glucose …

Leptin, discovered through positional cloning 15 years ago, is an adipocyte-secreted
hormone with pleiotropic effects in the physiology and pathophysiology of energy …

Background The hormone leptin is an important regulator of metabolic homeostasis, able to
inhibit food intake and increase energy expenditure. Leptin can also independently lower …

Leptin is an adipocyte-secreted hormone that has been proposed to regulate energy
homeostasis as well as metabolic, reproductive, neuroendocrine, and immune functions. In …

BACKGROUND Reproductive function is tightly regulated by nutritional status. Indeed, it has
been well described that undernutrition or obesity can lead to subfertility or infertility in …

Low-grade inflammation and insulin resistance are among the clinical features of obesity
that are thought to promote the progressive onset of type 2 diabetes. However, the …

Defective liver gluconeogenesis is the main mechanism leading to fasting hyperglycemia in
type 2 diabetes, and, in concert with steatosis, it is the hallmark of hepatic insulin resistance …

In normal aging, changes in the body composition occur that result in a shift toward
decreased muscle mass and increased fat mass. The loss of muscle mass that occurs with …

Glucose homeostasis is closely regulated not only by insulin, but also by leptin. Both
hormones act centrally, regulating food intake and adiposity in humans. Leptin has several …