Cell competition in intratumoral and tumor microenvironment interactions
TM Parker, K Gupta, AM Palma, M Yekelchyk… - The EMBO …, 2021 - embopress.org
Tumors are complex cellular and acellular environments within which cancer clones are
under continuous selection pressures. Cancer cells are in a permanent mode of interaction …
under continuous selection pressures. Cancer cells are in a permanent mode of interaction …
Metabolic heterogeneity of cancer cells: an interplay between HIF-1, GLUTs, and AMPK
NT Moldogazieva, IM Mokhosoev, AA Terentiev - Cancers, 2020 - mdpi.com
It has been long recognized that cancer cells reprogram their metabolism under hypoxia
conditions due to a shift from oxidative phosphorylation (OXPHOS) to glycolysis in order to …
conditions due to a shift from oxidative phosphorylation (OXPHOS) to glycolysis in order to …
A novel pyroptosis-related lncRNA signature for prognostic prediction in patients with lung adenocarcinoma
J Song, Y Sun, H Cao, Z Liu, L Xi, C Dong, R Yang… - …, 2021 - Taylor & Francis
Lung adenocarcinoma (LUAD) has been the major cause of tumor-associated mortality in
recent years and has a poor prognosis. Pyroptosis is regulated via the activation of …
recent years and has a poor prognosis. Pyroptosis is regulated via the activation of …
HIF-1α/JMJD1A signaling regulates inflammation and oxidative stress following hyperglycemia and hypoxia-induced vascular cell injury
M Zhao, S Wang, A Zuo, J Zhang, W Wen… - Cellular & Molecular …, 2021 - Springer
Background Endothelial cell (EC) injury accelerates the progression of diabetic
macrovascular complications. Hypoxia is an important cause of EC injury. Hypoxia-inducible …
macrovascular complications. Hypoxia is an important cause of EC injury. Hypoxia-inducible …
Inside the hypoxic tumour: reprogramming of the DDR and radioresistance
K Begg, M Tavassoli - Cell Death Discovery, 2020 - nature.com
The hypoxic tumour is a chaotic landscape of struggle and adaption. Against the adversity of
oxygen starvation, hypoxic cancer cells initiate a reprogramming of transcriptional activities …
oxygen starvation, hypoxic cancer cells initiate a reprogramming of transcriptional activities …
Hypoxia-mediated drug resistance in breast cancers
CE McAleese, C Choudhury, NJ Butcher, RF Minchin - Cancer letters, 2021 - Elsevier
Tissue hypoxia in solid tumors is caused by several pathological changes associated with
tumor growth, including altered microvasculature structure, increased diffusional distances …
tumor growth, including altered microvasculature structure, increased diffusional distances …
USP51 facilitates colorectal cancer stemness and chemoresistance by forming a positive feed-forward loop with HIF1A
M Mu, Q Zhang, J Li, C Zhao, X Li, Z Chen… - Cell Death & …, 2023 - nature.com
In the current study, we have shown that USP51 promotes colorectal cancer stemness and
chemoresistance, and high expression of USP51 predicts survival disadvantage in …
chemoresistance, and high expression of USP51 predicts survival disadvantage in …
Hypoxia-inducible factor is critical for pathogenesis and regulation of immune cell functions in rheumatoid arthritis
X Guo, G Chen - Frontiers in Immunology, 2020 - frontiersin.org
Rheumatoid arthritis (RA) is a common autoimmune disease with characteristics of synovial
inflammation, pannus formation, cartilage destruction, and bone erosion. Further, the …
inflammation, pannus formation, cartilage destruction, and bone erosion. Further, the …
Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1α/HMOX1 axis
J Shi, QH Wang, X Wei, B Huo, JN Ye, X Yi, X Feng… - Molecular …, 2023 - Springer
Abstract Background E1A-associated 300-kDa protein (P300), an endogenous histone
acetyltransferase, contributes to modifications of the chromatin landscape of genes involved …
acetyltransferase, contributes to modifications of the chromatin landscape of genes involved …
Hypoxia-inducible factor (HIF) in ischemic stroke and neurodegenerative disease
EV Mitroshina, MO Savyuk, E Ponimaskin… - Frontiers in cell and …, 2021 - frontiersin.org
Hypoxia is one of the most common pathological conditions, which can be induced by
multiple events, including ischemic injury, trauma, inflammation, tumors, etc. The body's …
multiple events, including ischemic injury, trauma, inflammation, tumors, etc. The body's …