Tumors are complex cellular and acellular environments within which cancer clones are
under continuous selection pressures. Cancer cells are in a permanent mode of interaction …

It has been long recognized that cancer cells reprogram their metabolism under hypoxia
conditions due to a shift from oxidative phosphorylation (OXPHOS) to glycolysis in order to …

Lung adenocarcinoma (LUAD) has been the major cause of tumor-associated mortality in
recent years and has a poor prognosis. Pyroptosis is regulated via the activation of …

Background Endothelial cell (EC) injury accelerates the progression of diabetic
macrovascular complications. Hypoxia is an important cause of EC injury. Hypoxia-inducible …

The hypoxic tumour is a chaotic landscape of struggle and adaption. Against the adversity of
oxygen starvation, hypoxic cancer cells initiate a reprogramming of transcriptional activities …

Tissue hypoxia in solid tumors is caused by several pathological changes associated with
tumor growth, including altered microvasculature structure, increased diffusional distances …

In the current study, we have shown that USP51 promotes colorectal cancer stemness and
chemoresistance, and high expression of USP51 predicts survival disadvantage in …

Rheumatoid arthritis (RA) is a common autoimmune disease with characteristics of synovial
inflammation, pannus formation, cartilage destruction, and bone erosion. Further, the …

Abstract Background E1A-associated 300-kDa protein (P300), an endogenous histone
acetyltransferase, contributes to modifications of the chromatin landscape of genes involved …

Hypoxia is one of the most common pathological conditions, which can be induced by
multiple events, including ischemic injury, trauma, inflammation, tumors, etc. The body's …