[PDF][PDF] Adaptive droplet routing in digital microfluidic biochips using deep reinforcement learning

TC Liang, Z Zhong - Proceedings of the 37th International Conference on …, 2020 - par.nsf.gov
We present and investigate a novel application domain for deep reinforcement learning
(RL): droplet routing on digital microfluidic biochips (DMFBs). A DMFB, composed of a …

Path scheduling on digital microfluidic biochips

D Grissom, P Brisk - Proceedings of the 49th Annual Design Automation …, 2012 - dl.acm.org
Since the inception of digital microfluidics, the synthesis problems of scheduling, placement
and routing have been performed offline (before runtime) due to their algorithmic complexity …

Dynamic adaptation using deep reinforcement learning for digital microfluidic biochips

TC Liang, YC Chang, Z Zhong, Y Bigdeli… - ACM Transactions on …, 2024 - dl.acm.org
We describe an exciting new application domain for deep reinforcement learning (RL):
droplet routing on digital microfluidic biochips (DMFBs). A DMFB consists of a two …

Fast online synthesis of digital microfluidic biochips

DT Grissom, P Brisk - … on Computer-Aided Design of Integrated …, 2014 - ieeexplore.ieee.org
We introduce an online synthesis flow, focusing primarily on the virtual topology and
operation binder, for digital microfluidic biochips, which will enable real-time response to …

Fast online synthesis of generally programmable digital microfluidic biochips

D Grissom, P Brisk - Proceedings of the eighth IEEE/ACM/IFIP …, 2012 - dl.acm.org
We introduce an online synthesis flow for digital microfluidic biochips, which will enable real-
time response to errors and control flow. The objective of this flow is to facilitate fast assay …

Error recovery in a micro-electrode-dot-array digital microfluidic biochip

Z Li, KYT Lai, PH Yu, K Chakrabarty… - 2016 IEEE/ACM …, 2016 - ieeexplore.ieee.org
A digital microfluidic biochip (DMFB) is an attractive technology platform for automating
laboratory procedures in biochemistry. However, today's DMFBs suffer from several …

A digital microfluidic biochip synthesis framework

D Grissom, K O'Neal, B Preciado… - 2012 IEEE/IFIP 20th …, 2012 - ieeexplore.ieee.org
Synthesis of digital microfluidic biochips (DMFBs) is a crucial to the advancement and
realization of miniaturized, automated, programmable biochemistry solutions; synthesis is …

Piracy prevention of digital microfluidic biochips

CW Hsieh, Z Li, TY Ho - 2017 22nd Asia and South Pacific …, 2017 - ieeexplore.ieee.org
Digital microfluidic biochips (DMFBs) play an important role in the healthcare industry due to
its advantages such as low-cost, portability, and efficiency. According to the recent market …

Machine learning with digital microfluidics for drug discovery and development

S Momtahen, F Al-Obaidy… - 2019 IEEE Canadian …, 2019 - ieeexplore.ieee.org
Drug discovery and development plays an increasing important role in biopharmaceutical
field. However, current drug discovery is slow, expensive, inefficient and error prone. Digital …

Reactant and waste minimization in multitarget sample preparation on digital microfluidic biochips

JD Huang, CH Liu, HS Lin - IEEE Transactions on Computer …, 2013 - ieeexplore.ieee.org
Sample preparation is one of essential processes in biochemical reactions. Raw reactants
are diluted in this process to achieve given target concentrations. A bioassay may require …