Metachromatic leukodystrophy is a lysosomal storage disease, which is characterized by
damage of the myelin sheath that covers most of nerve fibers of the central and peripheral …

This review is an effort towards the development of substrate reduction therapy using
cerebroside sulfotransferase (CST) as a target protein for the development of inhibitors …

Background Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder caused
by mutations in the arylsulfatase A gene (ARSA) and categorized into three subtypes …

Simple Summary Metabolic disorders (MD) are a challenge to healthcare systems; the
emergence of the modern socio-economic system has led to a profound change in lifestyles …

Metachromatic leukodystrophy (MLD) is an autosomal recessively inherited sulfatide storage
disease caused by deficient activity of the lysosomal enzyme arylsulfatase A (ASA). Genetic …

Arylsulfatases are lysosomal enzymes with important roles in the cell metabolism. Several
subtypes of arylsulfatase are known, from A to K. Congenital deficiencies of arylsulfatases …

Metachromatic leukodystrophy (MLD) is a neurodegenerative disorder characterized by
progressive demyelination due to deficiency of the enzyme arylsulfatase A (ARSA) in …

The arylsulfatase A (ARSA) gene is observed to be deficient in patients with metachromatic
leukodystrophy (MLD), a type of lysosomal storage disease. MLD is a severe …

Metachromatic leukodystrophy is a neurological disease of the lysosomal deposit that has a
significant impact given the implications for the neurodegenerative deterioration of the …

We assessed the utility of genome sequencing for early-onset dementia. Participants were
selected from a memory disorders clinic. Genome sequencing was performed along with …