Current medication for anxiety disorders is suboptimal in terms of efficiency and tolerability,
highlighting the need for improved drug treatments. In this review an overview of drugs …

Exposure-based treatments for clinical anxiety generally are very effective, but relapse is not
uncommon. Likewise, laboratory studies have shown that conditioned fears are easy to …

Post-traumatic stress disorder, panic disorder and phobia manifest in ways that are
consistent with an uncontrollable state of fear. Their development involves heredity, previous …

Anxiety disorders are the most prevalent group of psychiatric diseases, and have high
personal and societal costs. The search for novel pharmacological treatments for these …

Post-traumatic stress disorder (PTSD) is a psychiatric disorder associated with memories of
traumatic experiences. Conditioned fear memory, a representative model of traumatic …

Extinction of conditioned fear is an active learning process requiring N-methyl-D-aspartate
receptors (NMDARs), but the timing, location, and neural mechanisms of NMDAR-mediated …

Anxiety disorders are highly prevalent. Fear conditioning and extinction learning in animals
often serve as simple models of fear acquisition and exposure therapy of anxiety disorders …

In fear extinction, an animal learns that a conditioned stimulus (CS) no longer predicts a
noxious stimulus [unconditioned stimulus (UCS)] to which it had previously been associated …

NMDA receptors are important for the acquisition, reconsolidation, and extinction of
memories. NMDA receptor antagonists impair these memory processes, whereas the partial …

BACKGROUND: Translational research suggests that D-cycloserine (DCS), a partial N-
methyl-D-aspartate (NMDA) receptor agonist, might facilitate fear extinction and exposure …