The ESCRT proteins are an ancient system that buds membranes and severs membrane
necks from their inner face. Three “classical” functions of the ESCRT s have dominated …

Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or
lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key …

Eukaryotic cells have been confronted throughout their evolution with potentially lethal
plasma membrane injuries, including those caused by osmotic stress, by infection from …

The endosomal sorting complexes required for transport (ESCRT) drive multivesicular body
(MVB) biogenesis and cytokinetic abscission. Originally identified through genetics and cell …

Nitrogen-fixing rhizobia colonize legume roots via plant-made intracellular infection threads.
Genetics has identified some genes involved but has not provided sufficient detail to …

Selective trafficking of membrane proteins to lysosomes for destruction is required for proper
cell signalling and metabolism. Ubiquitylation aids this process by specifying which proteins …

The endosomal sorting complexes required for transport (ESCRTs) catalyse one of the most
unusual membrane remodelling events in cell biology. ESCRT-I and ESCRT-II direct …

Multivesicular bodies (MVBs) are unique organelles in the endocytic pathway that contain
vesicles in their lumen. Sorting and incorporation of material into such vesicles is a critical …

TSG101 and ALIX both function in HIV budding and in vesicle formation at the multivesicular
body (MVB), where they interact with other Endosomal Sorting Complex Required for …

During cytokinesis, as dividing animal cells pull apart into two daughter cells, the final stage,
termed abscission, requires breakage of the midbody, a thin membranous stalk connecting …