Clustered regularly interspaced short palindromic repeats (CRISPR) system provides
adaptive immunity against plasmids and phages in prokaryotes. This system inspires the …

Pancreatic ductal adenocarcinoma (PDAC) is an extremely aggressive type of cancer with
an overall survival rate of less than 7-8%, emphasizing the need for novel effective …

Nutrient stress in the tumor microenvironment requires cancer cells to adopt adaptive
metabolic programs for survival and proliferation. Therefore, knowledge of …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy that is
characterized by early metastasis, low resectability, high recurrence, and therapy resistance …

Osteosarcoma (OS) is the most common malignant bone tumor in children. Despite efforts to
develop and implement new therapies, patient outcomes have not measurably improved …

The Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated
protein 9 (CRISPR/Cas9) system, an RNA-based adaptive immune system found in bacteria …

For decades, tumor-bearing murine models established using tumor cell lines have been the
most commonly used models to study human cancers. Even though there are several …

Pancreatic ductal adenocarcinoma (PDAC) is a highly malignant disease, where even
surgical resection and aggressive chemotherapy produce dismal outcomes. Immunotherapy …

Pancreatic ductal adenocarcinoma (PDAC) is characterized by marked fibrosis and low
immunogenicity, features that are linked to treatment resistance and poor clinical outcomes …

With a very low survival rate, pancreatic ductal adenocarcinoma (PDAC) is a deadly
disease. This has been primarily attributed to (i) its late diagnosis and (ii) its high resistance …