RIG-I-like receptors (RLRs) are intracellular pattern recognition receptors that detect viral or
bacterial infection and induce host innate immune responses. The RLRs family comprises …

Patients who develop chronic fibrotic liver disease, caused by viral or metabolic aetiologies,
are at a high risk of developing hepatocellular carcinoma (HCC). Even after complete HCC …

Over the past decade, preclinical and clinical research have confirmed the essential role of
interferons for effective host immunological responses to malignant cells. Type I interferons …

Type I interferons (IFNs) are known for their key role in antiviral immune responses. In this
Review, we discuss accumulating evidence indicating that type I IFNs produced by …

Inflammation is emerging as one of the hallmarks of cancer, yet its role in most tumors
remains unclear. Whereas a minority of solid tumors are associated with overt inflammation …

Hepatocellular carcinoma (HCC) is an inflammation-induced and chemotherapy-resistant
cancer. Dysregulated signaling in the transforming growth factor beta (TGF-β) pathway plays …

Detection of evolutionarily conserved molecules on microbial pathogens by host immune
sensors represents the initial trigger of the immune response against infection. Cytosolic …

Astragalus polysaccharide (APS) has attracted growing interests in the field of anti-cancer by
direct killing effect and improving immune function. In this study, the structure and …

Interferon-α (IFNα) signaling is essential for antiviral response via induction of IFN-
stimulated genes (ISGs). Through a non-biased high-throughput RNAi screening of 711 …

Research on innate immune signaling and regulation has recently focused on pathogen
recognition receptors (PRRs) and their signaling pathways. Members of PRRs sense …