Construction of a nearly unbiased statistical estimator of sinogram to address CT number bias issues in low-dose photon counting CT

K Li, JR Chen, M Feng - IEEE Transactions on Medical Imaging, 2023 - ieeexplore.ieee.org
Photon counting detector (PCD)-CT has demonstrated promise to reduce ionizing radiation
exposure further and improve spatial resolution. However, when the radiation exposure or …

Unbiased zero-count correction method in low-dose high-resolution photon counting detector CT

D Bushe, R Zhang, GH Chen, K Li - Physics in Medicine & …, 2023 - iopscience.iop.org
Objective. To address the zero-count problem in low-dose, high-spatial-resolution photon
counting detector CT (PCD-CT) without introducing statistical biases or degrading spatial …

Photon counting-energy integrating hybrid flat panel detector systems for image-guided interventions: an experimental proof-of-concept

K Treb, Y Hämisch, C Ullberg… - Physics in Medicine & …, 2023 - iopscience.iop.org
Objective. Current C-arm x-ray systems equipped with scintillator-based flat panel detectors
(FPDs) lack sufficient low-contrast detectability and spectral, high-resolution capabilities …

Correcting statistical CT number biases without access to raw detector counts: Applications to high spatial resolution photon counting CT imaging

D Griner, N Lei, GH Chen, K Li - Medical physics, 2023 - Wiley Online Library
Background Due to the nonlinear nature of the logarithmic operation and the stochastic
nature of photon counts (N), sinogram data of photon counting detector CT (PCD‐CT) are …

High-resolution hybrid micro-CT imaging pipeline for mouse brain region segmentation and volumetric morphometry

R Nadkarni, ZY Han, RJ Anderson, AJ Allphin… - Plos one, 2024 - journals.plos.org
Background Brain region segmentation and morphometry in humanized apolipoprotein E
(APOE) mouse models with a human NOS2 background (HN) contribute to Alzheimer's …

A C-arm photon counting CT prototype with volumetric coverage using multi-sweep step-and-shoot acquisitions

K Treb, X Ji, M Feng, R Zhang… - Physics in Medicine …, 2022 - iopscience.iop.org
Objective. Existing clinical C-arm interventional systems use scintillator-based energy-
integrating flat panel detectors (FPDs) to generate cone-beam CT (CBCT) images. Despite …

Study on the impact of bowtie filter on photon-counting CT imaging

X Zhang, J Xie, T Su, J Zhu, D Xia… - Physics in Medicine …, 2024 - iopscience.iop.org
Objective: The aim of this study was to investigate the impact of the bowtie filter on the image
quality of the photon-counting detector (PCD) based CT imaging. Approach: Numerical …

Image quality improvement of a one-step spectral CT reconstruction on a prototype photon-counting scanner

PA Rodesch, SA Si-Mohamed, J Lesaint… - Physics in Medicine …, 2023 - iopscience.iop.org
Objective. X-ray spectral computed tomography (CT) allows for material decomposition
(MD). This study compared a one-step material decomposition MD algorithm with a two-step …

Overcoming the challenges of inaccurate CT numbers in low dose CT

JR Chen, M Feng, K Li - Medical Imaging 2022: Physics of …, 2022 - spiedigitallibrary.org
In recent years, much effort has been committed to lowering radiation dose in CT. However,
when the radiation dose is lowered, not only is image noise elevated, but the CT number …

Multi-energy CT material decomposition using graph model improved CNN

Z Shi, F Kong, M Cheng, H Cao, S Ouyang… - Medical & Biological …, 2024 - Springer
In spectral CT imaging, the coefficient image of the basis material obtained by the material
decomposition technique can estimate the tissue composition, and its accuracy directly …