The liver has a multitude of functions which are necessary to maintain whole body
homeostasis. This requires that various metabolic pathways can run in parallel in the most …

Acute kidney injury (AKI) is a major kidney disease characterized by an abrupt loss of renal
function. Accumulating evidence indicates that incomplete or maladaptive repair after AKI …

The hypoxia signalling pathway enables adaptation of cells to decreased oxygen
availability. When oxygen becomes limiting, the central transcription factors of the pathway …

Cardiovascular diseases are among the leading causes of death worldwide. Reactive
oxygen species (ROS) can act as damaging molecules but also represent central hubs in …

Reactive oxygen species (ROS), which are a byproduct of oxidative metabolism, serve as
signaling molecules in a number of physiological settings. However, if their levels are not …

The liver and its zonation contribute to whole body homeostasis. Acute and chronic, not
always liver, diseases impair proper metabolic zonation. Various underlying pathways, such …

The chromatin structure of the mammalian genome must facilitate both precisely-controlled
DNA replication together with tightly-regulated gene transcription. This necessarily involves …

Epitranscriptomics, the study of chemically modified RNAs, is a burgeoning field being
explored in a variety of scientific disciplines. Of the currently known epitranscriptomic …

Abstract Dimethylarginine dimethylaminohydrolase-1 (DDAH1) is overexpressed in prostate
cancer (PCa) and promotes PCa progression in in vivo through the ADMA-NO pathway by …

The redox sensitive transcription factor NRF2 is a central regulator of the transcriptional
response to reactive oxygen species (ROS). NRF2 is widely recognized for its ROS …