NF-κB in defense and disease ciated with inflammatory disease. Indeed, as discussed by
Tak and Firestein (this Perspective series), NF-κB is activated in the inflamed synovium of …

Apoptosis is a physiological process critical for organ development, tissue homeostasis, and
elimination of defective or potentially dangerous cells in complex organisms. Apoptosis can …

The transcription factor NF-κB is activated in a range of human cancers and is thought to
promote tumorigenesis, mainly due to its ability to protect transformed cells from apoptosis …

Rel/NF-κB transcription factors are key regulators of immune, inflammatory and acute phase
responses and are also implicated in the control of cell proliferation and apoptosis …

A major advance in the understanding of NF-κB regulation came with the identification of the
multisubunit IKK kinase complex, which contains two catalytic subunits, IKK-α and IKK-β …

Virus infections induce a proinflammatory response including expression of cytokines and
chemokines. The subsequent leukocyte recruitment and antiviral effector functions …

Rel/NF-kB transcription factors include a collection of proteins, conserved from Drosophila to
humans (Figure 1). Among model organisms, these transcription factors are notably absent …

Almost exactly twenty years after the discovery of Epstein-Barr virus (EBV), the latent
membrane protein 1 (LMP1) entered the EBV stage, and soon thereafter, it was recognized …

Chemotherapeutic agents simultaneously induce transcription factors p53 and NFκB. p53
induction can activate an apoptotic program, and resistance to chemotherapy correlates with …

Constitutive nuclear nuclear factor (NF)-κB activity is observed in a variety of hematopoietic
and solid tumors. Given the distinctive role of constitutive NF-κB for Hodgkin and Reed …