Bcl-2-associated X protein (BAX) is a critical executioner of mitochondrial regulated cell
death through its lethal activity of permeabilizing the mitochondrial outer membrane (MOM) …

The BCL-2 family of proteins controls cell death primarily by direct binding interactions that
regulate mitochondrial outer membrane permeabilization (MOMP) leading to the irreversible …

Mitochondrial apoptosis is strictly controlled by BCL-2 family proteins through a subtle
network of protein interactions. The tumor suppressor protein p53 triggers transcription …

The BCL2 inhibitor venetoclax induces high rates of durable remission in patients with
previously treated chronic lymphocytic leukemia (CLL). However, despite continuous daily …

Protein–protein interactions (PPIs) are of pivotal importance in the regulation of biological
systems and are consequently implicated in the development of disease states. Recent work …

The BCL-2 protein family determines the commitment of cells to apoptosis, an ancient cell
suicide programme that is essential for development, tissue homeostasis and immunity. Too …

Pyruvate kinase M2 isoform (PKM2) catalyzes the last step of glycolysis and plays an
important role in tumor cell proliferation. Recent studies have reported that PKM2 also …

During apoptotic cell death, cellular stress signals converge at the mitochondria to induce
mitochondrial outer-membrane permeabilization (MOMP) through B cell lymphoma-2 (BCL …

Venetoclax is a first-in-class cancer therapy that interacts with the cellular apoptotic
machinery promoting apoptosis. Treatment of patients suffering chronic lymphocytic …

During apoptosis, the BCL-2 protein family controls mitochondrial outer membrane
permeabilization (MOMP), but the dynamics of this regulation remain controversial. We …