Prevalence of polymorphisms in thiopurine metabolism and association with adverse outcomes: a South Asian region-specific systematic review and meta-analysis
Background: Prevalence and impact of thiopurine S-methyltransferase (TPMT) and Nudix
hydrolase (NUDT15) minor allele frequencies in South Asian population is unclear …
hydrolase (NUDT15) minor allele frequencies in South Asian population is unclear …
Incidence and determinants of hematotoxicity in acute lymphoblastic leukemia children who received 6-mercaptopurine based maintenance therapy in Addis Ababa …
AM Ali, H Adam, D Hailu, MJH Coenen, R Howe… - Plos one, 2023 - journals.plos.org
Introduction The maintenance phase of acute lymphoblastic leukemia treatment is the final
and longest stage of treatment, mainly focused on antimetabolite therapy. This phase is …
and longest stage of treatment, mainly focused on antimetabolite therapy. This phase is …
TPMT Genetic Variability and Its Association with Hematotoxicity in Indonesian Children with Acute Lymphoblastic Leukemia in Maintenance Therapy
DS Rosdiana, R Setiabudy, R Andalusia… - Pharmacogenomics …, 2021 - Taylor & Francis
Purpose Hematotoxicity monitoring in children with acute lymphoblastic leukemia (ALL) is
critical to preventing life-threatening infections and drug discontinuation. The primary drug …
critical to preventing life-threatening infections and drug discontinuation. The primary drug …
Understanding the role of genetics in childhood acute lymphoblastic leukemia
E Kampouraki, G N. Goulielmos… - World Academy of …, 2020 - spandidos-publications.com
Single nucleotide polymorphisms (SNPs), the most common type of genetic variation, are
important for the study of human diseases. Genome-wide association studies (GWAS) have …
important for the study of human diseases. Genome-wide association studies (GWAS) have …
In vitro cytotoxicity analysis on patient-derived PBMCs to predict 6-mercaptopurine therapy response in children with acute lymphoblastic leukemia
N Velugonda, D Patchva, SV Manda… - Indian Journal of …, 2024 - or.niscpr.res.in
Mercaptopurine (6-MP) is a critical medication used in the remission-maintenance phase of
pediatric acute lymphoblastic leukemia (ALL). Mercaptopurine has a narrow therapeutic …
pediatric acute lymphoblastic leukemia (ALL). Mercaptopurine has a narrow therapeutic …
Status of pharmacogenomics research in India during the last five years
R Priyadarshini, GM Raj, DG Shewade - 2018 - insajournal.in
Studies related to pharmacogenomics have considerably increased in recent years in India.
The interests shown by our researchers are largely reflecting the global trend towards the …
The interests shown by our researchers are largely reflecting the global trend towards the …
A clinical aid to precision medicine
Although we share 99.9% of our genes, no two humans are alike. The prediction of efficacy
and toxicity of drugs based on genetics is the science of pharmacogenomics. By the turn of …
and toxicity of drugs based on genetics is the science of pharmacogenomics. By the turn of …
Meta-analysis of the impact of thioprine S-methyltransferase polymorphisms on the tolerable 6-mercaptopurine dose considering initial dose and ethnic difference
MG Kim, M Ko, IW Kim, JM Oh - OncoTargets and therapy, 2016 - Taylor & Francis
A meta-analysis was conducted to decide whether to reduce an initial 6-mercaptopurine (6-
MP) dose in TPMT heterozygote in the case of an initial 6-MP dose of< 75 mg/m2/d and to …
MP) dose in TPMT heterozygote in the case of an initial 6-MP dose of< 75 mg/m2/d and to …
[PDF][PDF] Supplemental Material Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for thiopurine dosing based on TPMT and NUDT15 genotypes …
MV Relling, M Schwab, M Whirl-Carrillo… - files.cpicpgx.org
For TPMT, we searched the PubMed database from 1966 to October 2012 for the original
guideline and then Oct 1, 2012 to June 6, 2017 for this guideline update for keywords …
guideline and then Oct 1, 2012 to June 6, 2017 for this guideline update for keywords …
Μελέτη του ρόλου των πολυμορφισμών των γονιδίων FAS, CXCL12, TP53 και CYP1A1 στην οξεία λεμφοβλαστική λευχαιμία παιδιών και εφήβων
Ε Καμπουράκη - 2021 - didaktorika.gr
Η οξεία λεμφοβλαστική λευχαιμία (ΟΛΛ) είναι ο πιο συχνός τύπος λευχαιμίας στην παιδική
ηλικία. Αντιπροσωπεύει το ένα τρίτο όλων των νεοπλασιών που διαγιγνώσκονται σε παιδιά …
ηλικία. Αντιπροσωπεύει το ένα τρίτο όλων των νεοπλασιών που διαγιγνώσκονται σε παιδιά …