HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …

Vortioxetine, a novel antidepressant for the treatment of major depressive disorder (MDD), is
a 5-HT 3, 5-HT 7 and 5-HT 1D receptor antagonist, 5-HT 1B receptor partial agonist, 5-HT …

Upon receipt in the dorsal horn (DH) of the spinal cord, nociceptive (pain-signalling)
information from the viscera, skin and other organs is subject to extensive processing by a …

Triptans are a new class of compounds developed for the treatment of migraine attacks. The
first of the class, sumatriptan, and the newer triptans (zolmitriptan, naratriptan, rizatriptan …

Spreading depression (SD), a transient reversible phenomenon with characteristic ionic,
metabolic and hemodynamic changes, has been known for over 55 years. A vast number of …

It has become increasingly apparent that Parkinson's disease involves many transmitter
systems other than dopamine. This nondopaminergic involvement impacts on the …

Over 20 years ago, Deakin and Graeff hypothesized about the role of different serotonergic
pathways in controlling the behavioral and physiologic responses to aversive stimuli, and …

Synopsis Sumatriptan is a selective agonist at serotonin 5-HT I-like receptors, including 5-
HT 1B/1D subtypes. It is an effective treatment for acute migraine attacks and the injectable …

SUMMARY Serotonin or 5-hydroxytryptamine (5-HT) 1A receptors are widely expressed in
the brain and have extensive influence in the control of mood, cognition, movement and …

hydroxytryptamine receptor 5A (5-HT5A) belongs to the 5-HT receptor family and signals
through the Gi/o protein. It is involved in nervous system regulation and an attractive target …