Molecular detection of micrometastases and circulating tumor cells in solid tumors
RA Ghossein, S Bhattacharya, J Rosai - Clinical Cancer Research, 1999 - AACR
The detection of circulating tumor cells and micrometastases may have important prognostic
and therapeutic implications. Because their numbers can be very small, these tumor cells …
and therapeutic implications. Because their numbers can be very small, these tumor cells …
The prognostic value of circulating tumor cells in patients with melanoma: a systematic review and meta-analysis
Background: The detection of circulating tumor cells (CTC) in patients with melanoma
represents an appealing prognostic tool, but no consensus exists on this topic. We aimed to …
represents an appealing prognostic tool, but no consensus exists on this topic. We aimed to …
CD40-activated human B cells: an alternative source of highly efficient antigen presenting cells to generate autologous antigen-specific T cells for adoptive …
JL Schultze, S Michalak, MJ Seamon… - The Journal of …, 1997 - Am Soc Clin Investig
Multiple clinical trials have shown the efficacy of adoptively transferred allogeneic antigen-
specific T cells for the treatment of viral infections and relapsed hematologic malignancies …
specific T cells for the treatment of viral infections and relapsed hematologic malignancies …
Multiple mutation analyses in single tumor cells with improved whole genome amplification
W Dietmaier, A Hartmann, S Wallinger… - The American journal of …, 1999 - Elsevier
Combining whole genome amplification (WGA) methods with novel laser-based
microdissection techniques has made it possible to exploit recent progress in molecular …
microdissection techniques has made it possible to exploit recent progress in molecular …
Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of …
R Halaban, E Cheng, Y Zhang… - Proceedings of the …, 1997 - National Acad Sciences
The loss of tyrosinase, the key enzyme in melanin synthesis, has been implicated in the
dedifferentiation of malignant melanocytes. The presence of tyrosinase transcripts and …
dedifferentiation of malignant melanocytes. The presence of tyrosinase transcripts and …
Utilization of polymerase chain reaction technology in the detection of solid tumors
GV Raj, JG Moreno, LG Gomella - … International Journal of the …, 1998 - Wiley Online Library
BACKGROUND Most cancer detection tests currently performed are based on either
antibody assays to a marker protein with altered expression in cancer patients or on imaging …
antibody assays to a marker protein with altered expression in cancer patients or on imaging …
Detection of circulating urothelial cancer cells in the blood using the CellSearch System
M Naoe, Y Ogawa, J Morita, K Omori… - … Journal of the …, 2007 - Wiley Online Library
BACKGROUND. Circulating tumor cells (CTCs) have been shown to aid in the therapeutic
management of patients. But, only a few attempts have been made at the detection of …
management of patients. But, only a few attempts have been made at the detection of …
Prognostic significance of occult metastases detected by sentinel lymphadenectomy and reverse transcriptase–polymerase chain reaction in early-stage melanoma …
PJ Bostick, DL Morton, RR Turner, KT Huynh… - Journal of clinical …, 1999 - ascopubs.org
PURPOSE: Detection of micrometastases in the regional tumor-draining lymph nodes is
critical for accurate staging and prognosis in melanoma patients. We hypothesized that a …
critical for accurate staging and prognosis in melanoma patients. We hypothesized that a …
Molecular diagnostics in melanoma
JA Carlson, JS Ross, A Slominski, G Linette… - Journal of the American …, 2005 - Elsevier
Molecular pathology is rapidly evolving, featuring continuous technologic improvements that
offer novel clinical opportunities for the recognition of disease predisposition, for identifying …
offer novel clinical opportunities for the recognition of disease predisposition, for identifying …
Clinical significance of molecular detection of carcinoma cells in lymph nodes and peripheral blood by reverse transcription-polymerase chain reaction in patients with …
M Mori, K Mimori, H Ueo, K Tsuji, T Shiraishi… - Journal of clinical …, 1998 - ascopubs.org
PURPOSE This study evaluates the clinical significance of detection of carcinoembryonic
antigen (CEA) mRNA in the dissected lymph nodes and peripheral blood samples of …
antigen (CEA) mRNA in the dissected lymph nodes and peripheral blood samples of …