Targeting DNA damage response pathways in cancer
FJ Groelly, M Fawkes, RA Dagg, AN Blackford… - Nature Reviews …, 2023 - nature.com
Cells have evolved a complex network of biochemical pathways, collectively known as the
DNA damage response (DDR), to prevent detrimental mutations from being passed on to …
DNA damage response (DDR), to prevent detrimental mutations from being passed on to …
Artificial intelligence in histopathology: enhancing cancer research and clinical oncology
Artificial intelligence (AI) methods have multiplied our capabilities to extract quantitative
information from digital histopathology images. AI is expected to reduce workload for human …
information from digital histopathology images. AI is expected to reduce workload for human …
[HTML][HTML] Notch signaling pathway: architecture, disease, and therapeutics
B Zhou, W Lin, Y Long, Y Yang, H Zhang… - Signal transduction and …, 2022 - nature.com
The NOTCH gene was identified approximately 110 years ago. Classical studies have
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …
revealed that NOTCH signaling is an evolutionarily conserved pathway. NOTCH receptors …
NCCN guidelines® insights: Ovarian cancer, version 3.2022: Featured updates to the NCCN guidelines
DK Armstrong, RD Alvarez, FJ Backes… - Journal of the National …, 2022 - jnccn.org
Epithelial ovarian cancer is the leading cause of death from gynecologic cancer in the
United States, with less than half of patients living> 5 years following diagnosis. The NCCN …
United States, with less than half of patients living> 5 years following diagnosis. The NCCN …
Targeting replication stress in cancer therapy
AABA da Costa, D Chowdhury, GI Shapiro… - Nature reviews Drug …, 2023 - nature.com
Replication stress is a major cause of genomic instability and a crucial vulnerability of
cancer cells. This vulnerability can be therapeutically targeted by inhibiting kinases that …
cancer cells. This vulnerability can be therapeutically targeted by inhibiting kinases that …
[HTML][HTML] Multimodal data integration using machine learning improves risk stratification of high-grade serous ovarian cancer
KM Boehm, EA Aherne, L Ellenson, I Nikolovski… - Nature cancer, 2022 - nature.com
Patients with high-grade serous ovarian cancer suffer poor prognosis and variable response
to treatment. Known prognostic factors for this disease include homologous recombination …
to treatment. Known prognostic factors for this disease include homologous recombination …
Polyamines in cancer: integrating organismal metabolism and antitumour immunity
CE Holbert, MT Cullen, RA Casero Jr… - Nature Reviews …, 2022 - nature.com
The natural mammalian polyamines putrescine, spermidine and spermine are essential for
both normal and neoplastic cell function and replication. Dysregulation of metabolism of …
both normal and neoplastic cell function and replication. Dysregulation of metabolism of …
[HTML][HTML] Proteogenomic characterization of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer with poor patient
survival. Toward understanding the underlying molecular alterations that drive PDAC …
survival. Toward understanding the underlying molecular alterations that drive PDAC …
[HTML][HTML] Ovarian cancer mutational processes drive site-specific immune evasion
High-grade serous ovarian cancer (HGSOC) is an archetypal cancer of genomic instability,,–
patterned by distinct mutational processes,, tumour heterogeneity,–and intraperitoneal …
patterned by distinct mutational processes,, tumour heterogeneity,–and intraperitoneal …
A pan-cancer compendium of chromosomal instability
Chromosomal instability (CIN) results in the accumulation of large-scale losses, gains and
rearrangements of DNA. The broad genomic complexity caused by CIN is a hallmark of …
rearrangements of DNA. The broad genomic complexity caused by CIN is a hallmark of …