Mental illness modeling is still a major challenge for scientists. Animal models of
schizophrenia are essential to gain a better understanding of the disease etiopathology and …

Parvalbumin (PV) is a calcium binding protein expressed by inhibitory fast-spiking
interneurons in the cerebral cortex. By generating a fast stream of action potentials, PV+ …

Autism spectrum disorders (ASD) are a group of neurodevelopmental disorders with
symptoms including social deficits, anxiety, and communication difficulties. However, ASD …

Heat perception enables acute avoidance responses to prevent tissue damage and
maintain body thermal homeostasis. Unlike other modalities, how heat signals are …

Amyloid-β (Aβ) deposition occurs years before cognitive symptoms appear and is
considered a cause of Alzheimer9s disease (AD). The imbalance of Aβ production and …

Adult neurogenesis in the hippocampus may represent a form of plasticity in brain functions
including mood, learning and memory. However, mechanisms underlying neural …

Neurodevelopmental psychiatric disorders including schizophrenia (Sz) and attention deficit
hyperactivity disorder (ADHD) are chronic mental illnesses, which place costly and painful …

Schizophrenia is a complex genetic disorder, the non-Mendelian features of which are likely
complicated by epigenetic factors yet to be elucidated. Here, we performed RNA sequencing …

The proper development and function of neuronal circuits rely on a tightly regulated balance
between excitatory and inhibitory (E/I) synaptic transmission, and disrupting this balance can …

The precise control of the nervous system function under the vitality of synapses is extremely
critical. Efforts have been taken to explore the underlying cellular and molecular …