The intracellular calcium ions (Ca 2+) act as second messenger to regulate gene
transcription, cell proliferation, migration and death. Accumulating evidences have …

The interplay between Ca 2+ and reactive oxygen species (ROS) signaling pathways is well
established, with reciprocal regulation occurring at a number of subcellular locations. Many …

The calcium signal is implicated in a variety of processes important in tumor progression (eg
proliferation and invasiveness). The calcium signal has also been shown to be important in …

Apoptosis, a type of genetically controlled cell death, is a fundamental cellular mechanism
utilized by multicellular organisms for disposal of cells that are no longer needed or …

Cancer is a disease with marked heterogeneity in both response to therapy and survival.
Clinical and histopathological characteristics have long determined prognosis and therapy …

Abstract Calcium ions (Ca 2+) and the complex regulatory system governed by Ca 2+
signaling have been described to be of crucial importance in numerous aspects related to …

Protein misfolding is prominent in early cellular pathology of Alzheimer's disease (AD),
implicating pathophysiological significance of endoplasmic reticulum stress/unfolded protein …

Calcium (Ca2+) regulates a plethora of cellular functions including hallmarks of cancer
development such as cell cycle progression and cellular migration. Receptor-regulated …

In their seminal papers Hanahan and Weinberg described oncogenic processes a normal
cell undergoes to be transformed into a cancer cell. The functions of ion channels in the …

The remodeling of calcium homeostasis contributes to the cancer hallmarks and the
molecular mechanisms involved in calcium channel regulation in tumors remain to be …