Herpes simplex virus (HSV) establishes a latent infection in peripheral neurons and can
periodically reactivate to cause disease. Reactivation can be triggered by a variety of stimuli …

Axonal degeneration and neuronal cell death are fundamental processes in development
and contribute to the pathology of neurological disease in adults. Both processes are …

Most age-related neurodegenerative diseases remain incurable owing to an incomplete
understanding of the disease mechanisms. Several environmental and genetic factors …

Age-related macular degeneration (AMD) is a major cause of irreversible blindness among
the elderly population. Dysfunction and degeneration of the retinal pigment epithelial (RPE) …

In 1960, Rita Levi-Montalcini and Barbara Booker made an observation that transformed
neuroscience: as neurons mature, they become apoptosis resistant. The following year …

Stem cells offer the basis for the promotion of robust new therapeutic approaches for a
variety of human disorders. There are still many limitations to be overcome before clinical …

Protein S-nitrosylation is known to regulate enzymatic function. Here, we report that nitric
oxide (NO)-related species can contribute to Alzheimer's disease (AD) by S-nitrosylating the …

Cell death plays two major complementary roles in T cell biology: mediating the removal of
cells that are targeted by T cells and the removal of T cells themselves. T cells serve as …

Understanding the molecular mechanisms of herpes simplex virus 1 (HSV-1) latent infection
and reactivation in neurons requires the use of in vitro model systems. Establishing a …

The causes of grey matter pathology and diffuse neuron injury in MS remain incompletely
understood. Axonal stress signals arising from white matter lesions has been suggested to …