Therapeutic evolution of benzimidazole derivatives in the last quinquennial period
Benzimidazole, a fused heterocycle bearing benzene and imidazole has gained
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …
considerable attention in the field of contemporary medicinal chemistry. The moiety is of …
Antiplasmodial natural products: an update
N Tajuddeen, FR Van Heerden - Malaria journal, 2019 - Springer
Background Malaria remains a significant public health challenge in regions of the world
where it is endemic. An unprecedented decline in malaria incidences was recorded during …
where it is endemic. An unprecedented decline in malaria incidences was recorded during …
A Review of Approaches to the Metallic and Non-Metallic Synthesis of Benzimidazole (BnZ) and Their Derivatives for Biological Efficacy
M Patel, G Avashthi, A Gacem, MS Alqahtani, HK Park… - Molecules, 2023 - mdpi.com
Heterocyclic compounds are significant lead drug candidates based on their various
structure–activity relationships (SAR), and their use in pharmaceutics is constantly …
structure–activity relationships (SAR), and their use in pharmaceutics is constantly …
Antiprotozoal Activity-Based Profiling of a Dichloromethane Extract from Anthemis nobilis Flowers
M De Mieri, G Monteleone, I Ismajili… - Journal of natural …, 2017 - ACS Publications
A dichlomethane extract of Anthemis nobilis flower cones showed promising in vitro
antiprotozoal activity against Trypanosoma brucei rhodesiense and Leishmania donovani …
antiprotozoal activity against Trypanosoma brucei rhodesiense and Leishmania donovani …
Potential inhibitors of microglial activation from the roots of Vernicia montana Lour
Y Wang, G Chen, Q Meng, X Yao, Y Li, H Cao, B Lin… - Phytochemistry, 2022 - Elsevier
During our continuous investigation of natural, herbal inhibitors of microglial over-activation
in the Euphorbiaceae family, two plants of the Vernicia genus showed remarkable inhibitory …
in the Euphorbiaceae family, two plants of the Vernicia genus showed remarkable inhibitory …
Structurally diverse diterpenoids and phenanthrene derivatives from the roots of Baliospermum solanifolium
J Chen, Y Li, H Xu, M Lian, H Wang, D Zhu - Phytochemistry, 2024 - Elsevier
ABSTRACT Ten undescribed diterpenoids (1–10) and three undescribed phenanthrene
derivatives (11–13), together with seven known compounds, were isolated from the roots of …
derivatives (11–13), together with seven known compounds, were isolated from the roots of …
Phytochemistry and pharmacology of the genus Drypetes: A review
Aims Traditional medicinal use of species of the genus Drypetes is widespread in the
tropical regions. The aim of this review is to systematically appraise the literature available to …
tropical regions. The aim of this review is to systematically appraise the literature available to …
Plant-Based Secondary Compounds and Nutrients as Therapeutic Agents in the Management of Malaria Infection
Malaria is a vector-borne disease that is responsible for a large number of mortality globally.
The currently available synthetic antimalarial agents are affected with drug resistance. The …
The currently available synthetic antimalarial agents are affected with drug resistance. The …
Diterpenoids from Strophioblachia glandulosa and Their NLRP3 Inflammasome Inhibitory Effects
J Sakah Kaunda, YJ Xu, RH Zhang… - Chemistry & …, 2022 - Wiley Online Library
Our study on the roots and leaves of the never‐hitherto‐chemically studied S. glandulosa
led to the isolation of five new diterpenes, referred to as stroglandulons A–E (1–5) …
led to the isolation of five new diterpenes, referred to as stroglandulons A–E (1–5) …
Rapid screening using GIBEX screens-to-nature system of ethnomedicinal plants from Ngong Forest, Kenya for potency against infectious diseases and antioxidant …
Introduction: Plants from Kenyan flora are traditionally used to manage a number of ailments
including; chronic and infectious disease, to bolster the body immunity and for general …
including; chronic and infectious disease, to bolster the body immunity and for general …