The presence of single, non-motile “primary” cilia on the surface of epithelial cells has been
well described since the 1960s. However, for decades these organelles were believed to be …

The neocortex is the seat of higher cognitive functions and, in evolutionary terms, is the
youngest part of the mammalian brain. Since its origin, the neocortex has expanded in …

Cilia mediate an astonishing diversity of processes. Recent advances provide unexpected
insights into the regulatory mechanisms of cilium formation, and reveal diverse regulatory …

Both the basal body and the microtubule‐based axoneme it nucleates have evolutionarily
conserved subdomains crucial for cilium biogenesis, function and maintenance. Here, we …

Mutations affecting ciliary components cause ciliopathies. As described here, we
investigated Tectonic1 (Tctn1), a regulator of mouse Hedgehog signaling, and found that it is …

Mitochondrial Ca2+ uptake has key roles in cell life and death. Physiological Ca2+ signaling
regulates aerobic metabolism, whereas pathological Ca2+ overload triggers cell death …

During the last two to three decades, a large body of work has revealed the molecular basis
of many human disorders, including retinal and vitreoretinal degenerations and …

Centrioles/basal bodies (CBBs) are microtubule-based cylindrical organelles that nucleate
the formation of centrosomes, cilia, and flagella. CBBs, cilia, and flagella are ancestral …

Centrioles are barrel-shaped structures that are essential for the formation of centrosomes,
cilia, and flagella. Here we review recent advances in our understanding of the function and …

Meckel-Gruber syndrome (MKS), nephronophthisis (NPHP), and related ciliopathies present
with overlapping phenotypes and display considerable allelism between at least twelve …