Pathophysiology of sarcopenia: genetic factors and their interplay with environmental factors
AM Aslam, EB Ma, JY Huh - Metabolism, 2023 - Elsevier
Sarcopenia is a geriatric disorder characterized by a progressive decline in muscle mass
and function. This disorder has been associated with a range of adverse health outcomes …
and function. This disorder has been associated with a range of adverse health outcomes …
Aryl hydrocarbon receptor (AhR)-mediated signaling as a critical regulator of skeletal cell biology
DW Alhamad, H Bensreti, J Dorn… - Journal of …, 2022 - jme.bioscientifica.com
The aryl hydrocarbon receptor (AhR) has been implicated in regulating skeletal progenitor
cells and the activity of bone-forming osteoblasts and bone-resorbing osteoclasts, thereby …
cells and the activity of bone-forming osteoblasts and bone-resorbing osteoclasts, thereby …
Activation of the aryl hydrocarbon receptor in muscle exacerbates ischemic pathology in chronic kidney disease
N Balestrieri, V Palzkill, C Pass, J Tan… - Circulation …, 2023 - Am Heart Assoc
Background: Chronic kidney disease (CKD) accelerates the development of atherosclerosis,
decreases muscle function, and increases the risk of amputation or death in patients with …
decreases muscle function, and increases the risk of amputation or death in patients with …
Deletion of the aryl hydrocarbon receptor in endothelial cells improves ischemic angiogenesis in chronic kidney disease
VR Palzkill, J Tan, Q Yang, J Morcos… - American Journal …, 2024 - journals.physiology.org
Chronic kidney disease (CKD) is a strong risk factor for peripheral artery disease (PAD) that
is associated with worsened clinical outcomes. CKD leads to the accumulation of tryptophan …
is associated with worsened clinical outcomes. CKD leads to the accumulation of tryptophan …
Effect of gut microbiota-mediated tryptophan metabolism on inflammaging in frailty and sarcopenia
YS Xu, T Mao, YJ Wang, XS Qi, WJ Zhao… - The Journals of …, 2024 - academic.oup.com
Frailty syndrome refers to the nonspecific state of increased body vulnerability and
decreased antistress and recovery abilities after stress during aging. Sarcopenia is the …
decreased antistress and recovery abilities after stress during aging. Sarcopenia is the …
Psoralen and isopsoralen from Psoraleae Fructus aroused hepatotoxicity via induction of aryl hydrocarbon receptor-mediated CYP1A2 expression
C Zhang, JQ Zhao, JX Sun, HJ Li - Journal of Ethnopharmacology, 2022 - Elsevier
Abstract Ethnopharmacological relevance Psoraleae Fructus (PF), a traditional Chinese
medicine, has long been used to treat diseases such as cancer, osteoporosis and …
medicine, has long been used to treat diseases such as cancer, osteoporosis and …
[HTML][HTML] The 2022 On-site Padua Days on Muscle and Mobility Medicine hosts the University of Florida Institute of Myology and the Wellstone Center, March 30-April 3 …
In the autumn of 2021, the 2022 Padua Days of Muscle and Mobility Medicine (PDM3) was
planned to be held from March 30 to April 2, 2022. Despite the fact that Coronavirus COVID …
planned to be held from March 30 to April 2, 2022. Despite the fact that Coronavirus COVID …
Orchiectomy sensitizes cortical bone in male mice to the harmful effects of kynurenine
Kynurenine (Kyn) is a tryptophan metabolite that increases with age and promotes
musculoskeletal dysfunction. We previously found a sexually dimorphic pattern in how Kyn …
musculoskeletal dysfunction. We previously found a sexually dimorphic pattern in how Kyn …
Down-regulated Smyd1 participated in the inhibition of myoblast differentiation induced by cigarette smoke extract
F Li, M Xu, J Miao, N Hu, Y Wang, L Wang - Toxicology Letters, 2023 - Elsevier
The histone methyltransferase Smyd1 is essential for muscle development; however, its role
in smoking-induced skeletal muscle atrophy and dysfunction has not been investigated thus …
in smoking-induced skeletal muscle atrophy and dysfunction has not been investigated thus …
[HTML][HTML] Exercise and Ischemia-Activated Pathways in Limb Muscle Angiogenesis and Vascular Regeneration
VA Narkar - Methodist DeBakey Cardiovascular Journal, 2023 - ncbi.nlm.nih.gov
Exercise has a profound effect on cardiovascular disease, particularly through vascular
remodeling and regeneration. Peripheral artery disease (PAD) is one such cardiovascular …
remodeling and regeneration. Peripheral artery disease (PAD) is one such cardiovascular …