The ADAMs (a disintegrin and metalloproteinase) are a fascinating family of transmembrane
and secreted proteins with important roles in regulating cell phenotype via their effects on …

ADAM (a disintegrin and metalloprotease) proteins are membrane-anchored
metalloproteases that process and shed the ectodomains of membrane-anchored growth …

The matrix metalloproteinases and related A disintegrin and metalloproteinase enzymes are
implicated in various diseases of the nervous system. However, metalloproteinases are …

There is an exciting increase of evidence that members of the disintegrin and
metalloprotease (ADAM) family critically regulate cell adhesion, migration, development and …

ADAM metalloproteinase disintegrins have emerged as the major proteinase family that
mediates ectodomain shedding, the proteolytic release of extracellular domains from their …

Abstract Interleukin 6 (IL6) trans-signaling has emerged as a prominent regulator of immune
responses during both innate and acquired immunity. Regulation of IL6 trans-signaling is …

During neuronal development, neurotrophins are essential factors that promote survival,
differentiation and myelination of neurons. The trophic signals are relayed to the cells via …

TNF-α, a potent proinflammatory cytokine, is synthesized as a membrane-anchored
precursor and proteolytically released from cells. Soluble TNF is the primary mediator of …

γ-Secretase is a promiscuous protease that cleaves bitopic membrane proteins within the
lipid bilayer. Elucidating both the mechanistic basis of γ-secretase proteolysis and the …

Abstract 'A disintegrin and metalloproteases'(ADAMs) are a family of transmembrane
proteins with diverse functions in multicellular organisms. About half of the ADAMs are active …