cBAF complex components and MYC cooperate early in CD8+ T cell fate
The identification of mechanisms to promote memory T (Tmem) cells has important
implications for vaccination and anti-cancer immunotherapy,,–. Using a CRISPR-based …
implications for vaccination and anti-cancer immunotherapy,,–. Using a CRISPR-based …
ATP-dependent chromatin remodeling complexes as novel targets for cancer therapy
K Mayes, Z Qiu, A Alhazmi, JW Landry - Advances in cancer research, 2014 - Elsevier
The progression to advanced stage cancer requires changes in many characteristics of a
cell. These changes are usually initiated through spontaneous mutation. As a result of these …
cell. These changes are usually initiated through spontaneous mutation. As a result of these …
Diversity of small molecule HIV‐1 latency reversing agents identified in low‐and high‐throughput small molecule screens
P Hashemi, I Sadowski - Medicinal research reviews, 2020 - Wiley Online Library
The latency phenomenon produced by human immunodeficiency virus (HIV‐1) prevents
viral clearance by current therapies, and consequently development of a cure for HIV‐1 …
viral clearance by current therapies, and consequently development of a cure for HIV‐1 …
Small-molecule–directed, efficient generation of retinal pigment epithelium from human pluripotent stem cells
Age-related macular degeneration (AMD) is associated with dysfunction and death of retinal
pigment epithelial (RPE) cells. Cell-based approaches using RPE-like cells derived from …
pigment epithelial (RPE) cells. Cell-based approaches using RPE-like cells derived from …
mSWI/SNF promotes Polycomb repression both directly and through genome-wide redistribution
The mammalian SWI/SNF complex, or BAF complex, has a conserved and direct role in
antagonizing Polycomb-mediated repression. Yet, BAF also promotes repression by …
antagonizing Polycomb-mediated repression. Yet, BAF also promotes repression by …
Small molecule targeting of specific BAF (mSWI/SNF) complexes for HIV latency reversal
CA Marian, M Stoszko, L Wang, MW Leighty… - Cell chemical …, 2018 - cell.com
The persistence of a pool of latently HIV-1-infected cells despite combination anti-retroviral
therapy treatment is the major roadblock for a cure. The BAF (mammalian SWI/SNF) …
therapy treatment is the major roadblock for a cure. The BAF (mammalian SWI/SNF) …
Small molecule inhibitors of BAF; a promising family of compounds in HIV-1 latency reversal
Persistence of latently infected cells in presence of Anti-Retroviral Therapy presents the
main obstacle to HIV-1 eradication. Much effort is thus placed on identification of compounds …
main obstacle to HIV-1 eradication. Much effort is thus placed on identification of compounds …
Evolution of a strategy for preparing bioactive small molecules by sequential multicomponent assembly processes, cyclizations, and diversification
JJ Sahn, BA Granger, SF Martin - Organic & biomolecular chemistry, 2014 - pubs.rsc.org
A strategy for generating diverse collections of small molecules has been developed that
features a multicomponent assembly process (MCAP) to efficiently construct a variety of …
features a multicomponent assembly process (MCAP) to efficiently construct a variety of …
A Tox21 approach to altered epigenetic landscapes: assessing epigenetic toxicity pathways leading to altered gene expression and oncogenic transformation in vitro
CL Parfett, D Desaulniers - International journal of molecular sciences, 2017 - mdpi.com
An emerging vision for toxicity testing in the 21st century foresees in vitro assays assuming
the leading role in testing for chemical hazards, including testing for carcinogenicity. Toxicity …
the leading role in testing for chemical hazards, including testing for carcinogenicity. Toxicity …
ARID1A Regulates Transcription and the Epigenetic Landscape via POLE and DMAP1 While ARID1A Deficiency or Pharmacological Inhibition Sensitizes Germ Cell …
L Kurz, A Miklyaeva, MA Skowron, N Overbeck… - Cancers, 2020 - mdpi.com
Germ cell tumors (GCTs) are the most common solid malignancies found in young men.
Although they generally have high cure rates, metastases, resistance to cisplatin-based …
Although they generally have high cure rates, metastases, resistance to cisplatin-based …