Protein advanced glycation end products (AGE) formed by nonenzymatic glycation can
disrupt the normal structure and function of proteins, and stimulate the receptor for AGEs …

Background Glycation driven generation of advanced glycation end products (AGEs) and
their patho-physiological role in human degenerative diseases has remained one of the …

Advanced glycation end products (AGEs) are implicated in the pathology of Alzheimer's
disease (AD), as they induce neurodegeneration following interaction with the receptor for …

Methylglyoxal (MG) is a potent inducer of advanced glycation end products (AGEs). MG,
long considered a highly cytotoxic molecule with potential anticancer value, is now being re …

Abstract KRIT1 (CCM1) is a disease gene responsible for Cerebral Cavernous
Malformations (CCM), a major cerebrovascular disease of proven genetic origin affecting 0.3 …

Metastasis is the primary cause of death in prostate cancer (PC a) patients. Effective
therapeutic intervention in metastatic PC a is undermined by our poor understanding of its …

Simple Summary Metastatic prostate cancer (mPCa) is a well-known lethal condition. One of
the mechanisms through which PCa cells become so aggressive is the avoidance of …

Dicarbonyl stress is a dysfunctional state consisting in the abnormal accumulation of
reactive α-oxaldehydes leading to increased protein modification. In cells, post-translational …

Protein advanced glycation end products (AGEs) can be formed via nonenzymatic glycation
and accumulated intracellularly to disrupt cellular homeostasis for protein clearance. Here …

To date, thyroid cancers (TCs) remain a clinical challenge owing to their heterogeneous
nature. The etiopathology of TCs is associated not only with genetic mutations or …