Wnts are secreted, lipid-modified proteins that bind to different receptors on the cell surface
to activate canonical or non-canonical Wnt signaling pathways, which control various …

A remarkable interdisciplinary effort has unraveled the WNT (Wingless and INT-1) signal
transduction cascade over the last two decades. Wnt genes encode small secreted proteins …

Craniosynostosis results from premature fusion of the cranial suture (s), which contain
mesenchymal stem cells (MSCs) that are crucial for calvarial expansion in coordination with …

YAP (yes-associated protein) is a transcriptional factor that is negatively regulated by Hippo
pathway, a conserved pathway for the development and size control of multiple organs. The …

Both activating and null mutations of proteins required for canonical WNT signaling have
revealed the importance of this pathway for normal skeletal development. However, tissue …

The Wnt signaling pathway plays an important role not only in embryonic development but
also in the maintenance and differentiation of the stem cells in adulthood. In particular, Wnt …

Lgr5 marks adult stem cells in multiple adult organs and is a receptor for the Wnt‐agonistic R‐
spondins (RSPOs). Intestinal, stomach and liver Lgr5+ stem cells grow in 3D cultures to form …

The segmentation clock is an oscillating genetic network thought to govern the rhythmic and
sequential subdivision of the elongating body axis of the vertebrate embryo into somites: the …

Wnt/β-catenin signaling is a central regulator of adult stem cells. Variable sensitivity of Wnt
reporter transgenes, β-catenin's dual roles in adhesion and signaling, and hair follicle …

For more than a decade, Wnt signaling pathways have been the focus of intense research
activity in bone biology laboratories because of their importance in skeletal development …