TMEM16 proteins, also known as anoctamins, are involved in a variety of functions that
include ion transport, phospholipid scrambling, and regulation of other membrane proteins …

▪ Abstract Calcium-activated chloride channels (CaCCs) play important roles in cellular
physiology, including epithelial secretion of electrolytes and water, sensory transduction …

TMEM16A was found recently to be a calcium-activated Cl− channel (CaCC). CaCCs
perform important functions in cell physiology, including regulation of epithelial secretion …

Interest in the functions of intracellular chloride expanded about twenty years ago but mostly
this referred to tissues other than smooth muscle. On the other hand, accumulation of …

▪ Abstract Regulation of gastrointestinal (GI) motility is intimately coordinated with the
modulation of ionic conductances expressed in GI smooth muscle and nonmuscle cells …

Abbreviations: 4-AP, 4-aminopyridine; 5b-DHT, 5b-dihydrotestosterone; 5-HT, 5-
hydroxytrypamine; AR, androgen receptor; BaCl2, barium chloride; BKCa, calcium sensitive …

In smooth muscle cells (SMCs), the intracellular chloride ion (Cl−) concentration is high due
to accumulation by Cl−/HCO 3− exchange and Na+–K+–Cl− cotransportation. The …

Calcium signalling in smooth muscles is complex, but our understanding of it has increased
markedly in recent years. Thus, progress has been made in relating global Ca2+ signals to …

Background and Purpose T16Ainh‐A01 is a recently identified inhibitor of the calcium‐
activated chloride channel TMEM16A. The aim of this study was to test the efficacy of …

Calcium-activated chloride channels (ClCa) are ligand-gated anion channels as they have
been shown to be activated by a rise in intracellular Ca2+ concentration in various cell types …