[HTML][HTML] The pharmacological bases for repurposing statins in depression: a review of mechanistic studies
Statins are commonly prescribed medications widely investigated for their potential actions
on the brain and mental health. Pre-clinical and clinical evidence suggests that statins may …
on the brain and mental health. Pre-clinical and clinical evidence suggests that statins may …
[HTML][HTML] Anti-inflammatory strategies for schizophrenia: a review of evidence for therapeutic applications and drug repurposing
J Hong, M Bang - Clinical Psychopharmacology and Neuroscience, 2020 - ncbi.nlm.nih.gov
Schizophrenia is a debilitating psychiatric disorder with a substantial socioeconomic and
humanistic burden. Currently available treatment strategies mostly rely on antipsychotic …
humanistic burden. Currently available treatment strategies mostly rely on antipsychotic …
[HTML][HTML] Inter-individual differences in laboratory rats as revealed by three behavioural tasks
V Rudolfová, T Petrásek, E Antošová, D Frynta… - Scientific Reports, 2022 - nature.com
Stable inter-individual differences in behaviour and personality have been studied for
several decades now. The aim of this study was to test the repeatability of behaviour of the …
several decades now. The aim of this study was to test the repeatability of behaviour of the …
Adjunctive therapy with statins in schizophrenia patients: a meta-analysis and implications
H Shen, R Li, R Yan, X Zhou, X Feng, M Zhao… - Psychiatry Research, 2018 - Elsevier
There are some conflicting results regarding the benefit of adjunctive therapy with statins for
severity of negative symptoms in schizophrenia. This study aimed to verify whether statins …
severity of negative symptoms in schizophrenia. This study aimed to verify whether statins …
Serotonin Signaling through Lipid Membranes
LS Kalinichenko, J Kornhuber, S Sinning… - ACS Chemical …, 2024 - ACS Publications
Serotonin (5-HT) is a vital modulatory neurotransmitter responsible for regulating most
behaviors in the brain. An inefficient 5-HT synaptic function is often linked to various mental …
behaviors in the brain. An inefficient 5-HT synaptic function is often linked to various mental …
[HTML][HTML] Lipids, lipoprotein distribution and depressive symptoms: the Multi-Ethnic Study of Atherosclerosis
Previous studies suggest lower concentrations of total and high-density lipoprotein (HDL)
cholesterol to be predictive of depression. We therefore investigated the relationship of lipids …
cholesterol to be predictive of depression. We therefore investigated the relationship of lipids …
Low cholesterol, impulsivity and violence revisited
K Tomson-Johanson, J Harro - Current Opinion in Endocrinology …, 2018 - journals.lww.com
Low cholesterol, impulsivity and violence revisited : Current Opinion in Endocrinology,
Diabetes and Obesity Low cholesterol, impulsivity and violence revisited : Current Opinion in …
Diabetes and Obesity Low cholesterol, impulsivity and violence revisited : Current Opinion in …
Selective inhibition of intestinal 5-HT improves neurobehavioral abnormalities caused by high-fat diet mice
Q Pan, Q Liu, R Wan, PK Kalavagunta, L Liu, W Lv… - Metabolic brain …, 2019 - Springer
Recent literature reported the adverse effects of high-fat diet (HFD) on animal's emotional
and cognitive function. An HFD-induced obesity/hyperlipidemia is accompanied by …
and cognitive function. An HFD-induced obesity/hyperlipidemia is accompanied by …
Simvastatin exerts antidepressant-like activity in mouse forced swimming test: Role of NO-cGMP-KATP channels pathway and PPAR-gamma receptors
R Naserzadeh, N Abad, B Ghorbanzadeh… - Pharmacology …, 2019 - Elsevier
Simvastatin, one of the lipophilic statins, has been shown to be effective in reducing
depression in rodents. The present study aimed to investigate the potential antidepressant …
depression in rodents. The present study aimed to investigate the potential antidepressant …
[PDF][PDF] Statin-induced changes in mitochondrial respiration in blood platelets in rats and human with dyslipidemia.
J Vevera, Z Fišar, T Nekovářová, M Vrablík… - Physiological …, 2016 - academia.edu
Statins, HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) reductase inhibitors, have been
demonstrated to reduce all-cause mortality and the risk of major cardiovascular events …
demonstrated to reduce all-cause mortality and the risk of major cardiovascular events …