BACKGROUND Ribosomopathies are a heterogeneous group of human disorders that are
in some cases known, and in other cases suspected, to result from ribosome dysfunction …

Ribosome profiling, which involves the deep sequencing of ribosome-protected mRNA
fragments, is a powerful tool for globally monitoring translation in vivo. The method has …

Ageing is accompanied by a decline in cellular proteostasis, which underlies many age-
related protein misfolding diseases,. Yet, how ageing impairs proteostasis remains unclear …

Aberrantly slow translation elicits quality control pathways initiated by the ubiquitin ligase
ZNF598. How ZNF598 discriminates physiologic from pathologic translation complexes and …

Translating ribosomes that slow excessively incur collisions with trailing ribosomes.
Persistent collisions are detected by ZNF598, a ubiquitin ligase that ubiquitinates sites on …

Ribosome profiling has emerged as a technique for measuring translation comprehensively
and quantitatively by deep sequencing of ribosome-protected mRNA fragments. By …

The ribosome-associated protein quality control (RQC) system that resolves stalled
translation events is activated when ribosomes collide and form disome, trisome, or higher …

Ribosome profiling suggests that ribosomes occupy many regions of the transcriptome
thought to be noncoding, including 5′ UTRs and long noncoding RNAs (lncRNAs) …

Protein synthesis by the ribosome can fail for numerous reasons including faulty mRNA,
insufficient availability of charged tRNAs and genetic errors. All organisms have evolved …

During protein synthesis, ribosomes encounter many roadblocks, the outcomes of which are
largely determined by substrate availability, amino acid features and reaction kinetics …