Mucinous colorectal adenocarcinoma is a distinct subtype of colorectal cancer (CRC)
characterized by the presence of abundant extracellular mucin which accounts for at least …

Colorectal cancer (CRC) is the second most common cancer in women and the third most
common in men globally. CRC arises from one or a combination of chromosomal instability …

Background Clinical studies regarding colorectal cancer (CRC) have suggested differences
in metastatic patterns between mucinous adenocarcinoma (MC), signet-ring cell carcinoma …

OBJECTIVES: Evidence suggests a possible role ofFusobacterium nucleatumin colorectal
carcinogenesis, especially in right-sided proximal colorectum. Considering a change in …

BRAF mutation in colorectal cancer is associated with microsatellite instability (MSI) through
its relationship with high-level CpG island methylator phenotype (CIMP) and MLH1 promoter …

Colorectal cancer (CRC) is increasingly appreciated as a heterogeneous disease, with
factors such as microsatellite instability (MSI), cancer subsite within the colon versus rectum …

Background: Activating mutations in KRAS have been suggested as potential predictive and
prognostic biomarkers. However, the prognostic impact of specific point mutations remains …

Immunotherapy strategies targeting immune checkpoints such as the CTLA4 and CD274
(programmed cell death 1 ligand 1, PD-L1)/PDCD1 (programmed cell death 1, PD-1) T-cell …

The term 'field effect'(also known as field defect, field cancerization, or field carcinogenesis)
has been used to describe a field of cellular and molecular alteration, which predisposes to …

Importance Aspirin use reduces the risk of colorectal carcinoma. Experimental evidence
implicates a role of RAF kinases in up-regulation of prostaglandin-endoperoxide synthase 2 …