KRAS oncogene in non-small cell lung cancer: clinical perspectives on the treatment of an old target

M Román, I Baraibar, I López, E Nadal, C Rolfo… - Molecular cancer, 2018 - Springer
Lung neoplasms are the leading cause of death by cancer worldwide. Non-small cell lung
cancer (NSCLC) constitutes more than 80% of all lung malignancies and the majority of …

Roles of DNA repair enzyme OGG1 in innate immunity and its significance for lung cancer

S Vlahopoulos, M Adamaki, N Khoury… - Pharmacology & …, 2019 - Elsevier
Cytokines are pivotal mediators of the immune response, and their coordinated expression
protects host tissue from excessive damage and oxidant stress. Nevertheless, the …

[HTML][HTML] Personalized medicine in non-small cell lung cancer: a review from a pharmacogenomics perspective

W Jiang, G Cai, PC Hu, Y Wang - Acta pharmaceutica sinica B, 2018 - Elsevier
Non-small cell lung cancer is a prevalent and rapidly-expanding challenge to modern
medicine. While generalized medicine with traditional chemotherapy yielded comparatively …

Nivolumab versus docetaxel for previously treated advanced non-small cell lung cancer in China: a cost-effectiveness analysis

Q Liu, X Luo, L Peng, L Yi, X Wan, X Zeng… - Clinical drug …, 2020 - Springer
Abstract Background and Objective The economic assessment of immuno-oncology agents
in Chinese patients is limited despite a need for new therapies. Nivolumab is the first …

CRISPR and KRAS: a match yet to be made

G Bender, R Fahrioglu Yamaci, B Taneri - Journal of biomedical science, 2021 - Springer
CRISPR (clustered regularly interspaced short palindromic repeats) systems are one of the
most fascinating tools of the current era in molecular biotechnology. With the ease that they …

Cost-effectiveness of osimertinib as a second-line treatment in patients with EGFR-mutated advanced non–small cell lung cancer in China

H Guan, G Liu, F Xie, Y Sheng, L Shi - Clinical Therapeutics, 2019 - Elsevier
Purpose To assess the cost-effectiveness of osimertinib used as a second-line treatment
after failure of epidermal growth factor receptor tyrosine kinase inhibitor therapy for …

[HTML][HTML] Precision medicine in non communicable diseases

M Hasanzad, N Sarhangi, HRA Meybodi… - … Journal of Molecular …, 2019 - ncbi.nlm.nih.gov
Non-communicable diseases (NCDs) are the leading cause of death and disease burden
globally, cardiovascular diseases (CVDs) account for the major part of death related to …

Cost-effectiveness of alectinib for patients with untreated ALK-positive non-small cell lung cancer in China

H Guan, Y Sheng, W Guo, S Han, L Shi - Advances in Therapy, 2019 - Springer
Introduction To assess the cost-effectiveness of alectinib versus crizotinib as first-line
treatments for advanced anaplastic lymphoma kinase (ALK)-positive non-small cell lung …

Cost-effectiveness analysis of adding ramucirumab to the first-line erlotinib treatment for untreated EGFR-mutated metastatic non-small cell lung cancer in China

Q Liu, X Luo, L Peng, L Yi, X Wan, X Zeng, C Tan - BMJ open, 2020 - bmjopen.bmj.com
Objective To investigate the cost-effectiveness of ramucirumab plus erlotinib compared with
placebo plus erlotinib in the first-line setting for patients with EGFR-mutated metastatic non …

[HTML][HTML] Magnesium intake and lung cancer risk: A systematic review and meta-analysis

N Dana, R Karimi, M Mansourian… - … Journal for Vitamin …, 2019 - econtent.hogrefe.com
Magnesium may reduce the risk of lung cancer by affecting cell proliferation, inflammation
and by preserving lung function; however, the results of epidemiological studies on the …