Ageing, age-related diseases and oxidative stress: What to do next?

J Luo, K Mills, S le Cessie, R Noordam… - Ageing research …, 2020 - Elsevier
Among other mechanisms, oxidative stress has been postulated to play an important role in
the rate of ageing. Oxidative damage contributes to the hallmarks of ageing and essential …

[HTML][HTML] Thinking outside the nucleus: Mitochondrial DNA copy number in health and disease

CA Castellani, RJ Longchamps, J Sun, E Guallar… - Mitochondrion, 2020 - Elsevier
Mitochondrial DNA copy number (mtDNA-CN) is a biomarker of mitochondrial function and
levels of mtDNA-CN have been reproducibly associated with overall mortality and a number …

Blood mitochondrial DNA copy number: what are we counting?

M Picard - Mitochondrion, 2021 - Elsevier
There is growing scientific interest to develop scalable biological measures that capture
mitochondrial (dys) function. Mitochondria have their own genome, the mitochondrial DNA …

Mitochondrial ROS‐Modulated mtDNA: a potential target for cardiac aging

Y Quan, Y Xin, G Tian, J Zhou… - Oxidative medicine and …, 2020 - Wiley Online Library
Mitochondrial DNA (mtDNA) damage is associated with the development of cardiovascular
diseases. Cardiac aging plays a central role in cardiovascular diseases. There is …

Environmental chemical exposures and mitochondrial dysfunction: a review of recent literature

A Reddam, S McLarnan, A Kupsco - Current environmental health reports, 2022 - Springer
Abstract Purpose of Review Mitochondria play various roles that are important for cell
function and survival; therefore, significant mitochondrial dysfunction may have chronic …

A healthy lifestyle is positively associated with mental health and well-being and core markers in ageing

P Hautekiet, ND Saenen, DS Martens, M Debay… - BMC medicine, 2022 - Springer
Background Studies often evaluate mental health and well-being in association with
individual health behaviours although evaluating multiple health behaviours that co-occur in …

NRF2 and mitochondrial function in cancer and cancer stem cells

E Panieri, SA Pinho, GJM Afonso, PJ Oliveira… - Cells, 2022 - mdpi.com
The NRF2–KEAP1 system is a fundamental component of the cellular response that controls
a great variety of transcriptional targets that are mainly involved in the regulation of redox …

Inheritance through the cytoplasm

MF Camus, B Alexander-Lawrie, J Sharbrough… - Heredity, 2022 - nature.com
Most heritable information in eukaryotic cells is encoded in the nuclear genome, with
inheritance patterns following classic Mendelian segregation. Genomes residing in the …

Association of mitochondrial DNA copy number with metabolic syndrome and type 2 diabetes in 14 176 individuals

F Fazzini, C Lamina, A Raftopoulou… - Journal of Internal …, 2021 - Wiley Online Library
Background Mitochondria play an important role in cellular metabolism, and their
dysfunction is postulated to be involved in metabolic disturbances. Mitochondrial DNA is …

Evaluation of mitochondrial DNA copy number estimation techniques

RJ Longchamps, CA Castellani, SY Yang… - PloS one, 2020 - journals.plos.org
Mitochondrial DNA copy number (mtDNA-CN), a measure of the number of mitochondrial
genomes per cell, is a minimally invasive proxy measure for mitochondrial function and has …