Bacterial genomes are remarkably stable from one generation to the next but are plastic on
an evolutionary time scale, substantially shaped by horizontal gene transfer, genome …

The importance of safer approaches for gene therapy has been underscored by a series of
severe adverse events (SAEs) observed in patients involved in clinical trials for Severe …

James A. Shapiro proposes an important new paradigm for understanding biological
evolution, the core organizing principle of biology. Shapiro introduces crucial new molecular …

Bacteriophages or phages—viruses of bacteria—are abundant and considered to be highly
diverse. Interestingly, a particular group of lytic Vibrio cholerae–specific phages …

The increase of publicly available sequencing data has allowed for rapid progress in our
understanding of genome composition. As new information becomes available we should …

Rice production needs to be sustained in the coming decades, as the changeable climatic
conditions are becoming more conducive to disease outbreaks. The majority of rice …

Cancer is a severe disease that substantially jeopardizes global health. Although
considerable efforts have been made to discover effective anti-cancer therapeutics, the …

Fungal mitochondrial (mt) genomes exhibit great diversity in size which is partially attributed
to their variable intergenic regions and most importantly to the inclusion of introns within …

Introns are ubiquitous in eukaryotic genomes and have long been considered as 'junk
RNA'but the huge energy expenditure in their transcription, removal, and degradation …

Mobile genetic elements, elements that can move horizontally between genomes, have
profound effects on their host's fitness. The p hage-inducible chromosomal island-l ike e …