The secreted glycoprotein leucine-rich α-2 glycoprotein 1 (LRG1) was first described as a
key player in pathogenic ocular neovascularization almost a decade ago. Since then, an …

Adipocytes are one of the primary stromal cells in many tissues, and they are considered to
play an active role in the tumor microenvironment. Cancer-associated adipocytes (CAAs) …

Cancer stem-like cells (CSC) play pivotal roles in both chemoresistance and recurrence of
many cancer types, including urothelial bladder cancer (UBC). In addition to intrinsic …

Background Breast cancer (BC), the second most common cause of cancer-related deaths,
remains a significant threat to the health and wellness of women worldwide. The tumor …

Background Obesity is associated with increased recurrence and reduced survival of breast
cancer. Adipocytes constitute a significant component of breast tissue, yet their role in …

IL-22 is a relatively new cytokine that is characterized by several unique biological
properties. In the intestines, the effect of IL-22 is restricted mainly to non-lymphoid cells such …

Significance: In the last years, metabolic reprogramming, fluctuations in bioenergetic fuels,
and modulation of oxidative stress became new key hallmarks of tumor development. In …

Background Emerging evidence supports the pivotal roles of adipocytes in breast cancer
progression. Tumour induced beige/brown adipose tissue differentiation contributes to the …

Epithelial–mesenchymal plasticity (EMP) plays critical roles during embryonic development,
wound repair, fibrosis, inflammation and cancer. During cancer progression, EMP results in …

Background Tumor-associated neutrophils (TANs) and macrophages (TAMs) can each
influence cancer growth and metastasis, but their combined effects in intrahepatic …