Efforts to determine the antibody repertoire encoded by B cells in the blood or lymphoid
organs using high-throughput DNA sequencing technologies have been advancing at an …

Many aspects of SARS-CoV-2 have fully conformed with the principles established by
decades of viral immunology research, ultimately leading to the crowning achievement of …

Accumulation of human CD21low B cells in peripheral blood is a hallmark of chronic
activation of the adaptive immune system in certain infections and autoimmune disorders …

The diversity of circulating human B cells is unknown. We use single-cell RNA sequencing
(RNA-seq) to examine the diversity of both antigen-specific and total B cells in healthy …

Multiple studies have shown loss of severe acute respiratory syndrome coronavirus 2–
specific (SARS-CoV-2–specific) antibodies over time after infection, raising concern that …

Protective antibodies in Plasmodium falciparum malaria are only acquired after years of
repeated infections. Chronic malaria exposure is associated with a large increase in atypical …

Malaria is a mosquito-borne disease caused by parasites of the obligate intracellular
Apicomplexa phylum the most deadly of which, Plasmodium falciparum, prevails in Africa …

In this study, we report that antigen-specific CD19+ CD27+ CD21lo (CD21lo) B cells are
transiently induced 14 to 28 days after immunization, at the time germinal centers (GCs) …

Immunological memory is a remarkable phenomenon in which survival of an initial infection
by a pathogen leads to life-long protection from disease upon subsequent exposure to that …

Malaria remains a significant contributor to the global burden of disease, with around 40% of
the world's population at risk of Plasmodium infections. The development of an effective …