Tumor vascularization occurs through several distinct biological processes, which not only
vary between tumor type and anatomic location, but also occur simultaneously within the …

Address reprint requests to Barrett J. Rollins, MD, PhD, Dana-kines than humans (for
example, there is no clear-cut murine Farber Cancer Institute, 44 Binney St, Boston, MA …

IL-8, a member of the chemokine family, has been shown to play an important role in tumor
growth, angiogenesis, and metastasis. The objective of this study was to determine the …

Infection and chronic inflammation contribute to about 1 in 4 of all cancer cases. Mediators of
the inflammatory response, eg, cytokines, free radicals, prostaglandins and growth factors …

Persistent infection or chronic inflammation contributes significantly to tumourigenesis and
tumour progression. CXC motif ligand 8 (CXCL8) is a chemokine that acts as an important …

In this study, we demonstrate that the CXC family of chemokines displays disparate
angiogenic activity depending upon the presence or absence of the ELR motif. CXC …

We examine here several diseases that are associated with inappropriate activation of the
chemokine network. Detailed comment has been restricted to pathological states for which …

Neutrophil extracellular traps (NETs) are a defense mechanism first described to trap and kill
bacteria and other pathogens. Increasingly, however, their involvement in the pathogenesis …

The role of Ras oncogenes in promoting cellular transformation is well established.
However, the contribution of Ras signaling to interactions between tumor cells and their host …

The aggressive nature of metastatic human cancer has been shown to be related to
numerous abnormalities in growth factors and their receptors. These perturbations confer a …