Cholesterol is an essential component of eukaryotic cellular membranes. Information about
its subcellular localization and transport pathways inside cells are key for the understanding …

Lipids play an essential role in the structure of the endosomal membranes as well as in their
dynamic rearrangement during the transport of internalized cargoes along the endocytic …

Exosomes are extracellular vesicles that are released when endosomes fuse with the
plasma membrane. They have been implicated in various functions in both health and …

Cholesterol import in mammalian cells is mediated by the LDL receptor pathway. Here, we
perform a genome-wide CRISPR screen using an endogenous cholesterol reporter and …

Multiple membrane organelles require cholesterol for proper function within cells. The
Niemann-Pick type C (NPC) proteins export cholesterol from endosomes to other membrane …

In our search for bioactive metabolites from marine organisms, we have investigated the
polar fraction of the organic extract of the Red Sea sponge Theonella swinhoei. Successive …

Although sphingomyelin and cholesterol are major lipids of mammalian cells, the detailed
distribution of these lipids in cellular membranes remains still obscure. However, the recent …

Covering: up to 2019 Nature furnishes bioactive compounds (natural products) with complex
chemical structures, yet with simple, sophisticated molecular mechanisms. When natural …

Niemann-Pick type C1 disease (NPC1) is a fatal genetic disorder caused by impaired
intracellular cholesterol trafficking. Recent studies reported ototoxicity of 2-hydroxypropyl-β …

Cholesterol is a fundamental lipid component of eukaryotic membranes and a precursor of
potent signaling molecules, such as oxysterols and steroid hormones. Cholesterol and …