Cellular cholesterol and how to find it
V Schoop, A Martello, ER Eden, D Höglinger - Biochimica et Biophysica …, 2021 - Elsevier
Cholesterol is an essential component of eukaryotic cellular membranes. Information about
its subcellular localization and transport pathways inside cells are key for the understanding …
its subcellular localization and transport pathways inside cells are key for the understanding …
Lipid compartmentalization in the endosome system
F Hullin-Matsuda, T Taguchi, P Greimel… - Seminars in cell & …, 2014 - Elsevier
Lipids play an essential role in the structure of the endosomal membranes as well as in their
dynamic rearrangement during the transport of internalized cargoes along the endocytic …
dynamic rearrangement during the transport of internalized cargoes along the endocytic …
Tetherin is an exosomal tether
Exosomes are extracellular vesicles that are released when endosomes fuse with the
plasma membrane. They have been implicated in various functions in both health and …
plasma membrane. They have been implicated in various functions in both health and …
A trimeric Rab7 GEF controls NPC1-dependent lysosomal cholesterol export
DJH van den Boomen, A Sienkiewicz, I Berlin… - Nature …, 2020 - nature.com
Cholesterol import in mammalian cells is mediated by the LDL receptor pathway. Here, we
perform a genome-wide CRISPR screen using an endogenous cholesterol reporter and …
perform a genome-wide CRISPR screen using an endogenous cholesterol reporter and …
Acat1/Soat1 knockout extends the mutant Npc1 mouse lifespan and ameliorates functional deficiencies in multiple organelles of mutant cells
Multiple membrane organelles require cholesterol for proper function within cells. The
Niemann-Pick type C (NPC) proteins export cholesterol from endosomes to other membrane …
Niemann-Pick type C (NPC) proteins export cholesterol from endosomes to other membrane …
Theonellamide G, a Potent Antifungal and Cytotoxic Bicyclic Glycopeptide from the Red Sea Marine Sponge Theonella swinhoei
In our search for bioactive metabolites from marine organisms, we have investigated the
polar fraction of the organic extract of the Red Sea sponge Theonella swinhoei. Successive …
polar fraction of the organic extract of the Red Sea sponge Theonella swinhoei. Successive …
Detectors for evaluating the cellular landscape of sphingomyelin-and cholesterol-rich membrane domains
T Kishimoto, R Ishitsuka, T Kobayashi - … BBA)-Molecular and Cell Biology of …, 2016 - Elsevier
Although sphingomyelin and cholesterol are major lipids of mammalian cells, the detailed
distribution of these lipids in cellular membranes remains still obscure. However, the recent …
distribution of these lipids in cellular membranes remains still obscure. However, the recent …
Chemical diversity and mode of action of natural products targeting lipids in the eukaryotic cell membrane
S Nishimura, N Matsumori - Natural product reports, 2020 - pubs.rsc.org
Covering: up to 2019 Nature furnishes bioactive compounds (natural products) with complex
chemical structures, yet with simple, sophisticated molecular mechanisms. When natural …
chemical structures, yet with simple, sophisticated molecular mechanisms. When natural …
Susceptibility of outer hair cells to cholesterol chelator 2-hydroxypropyl-β-cyclodextrine is prestin-dependent
S Takahashi, K Homma, Y Zhou, S Nishimura… - Scientific reports, 2016 - nature.com
Niemann-Pick type C1 disease (NPC1) is a fatal genetic disorder caused by impaired
intracellular cholesterol trafficking. Recent studies reported ototoxicity of 2-hydroxypropyl-β …
intracellular cholesterol trafficking. Recent studies reported ototoxicity of 2-hydroxypropyl-β …
Bioorthogonal probes for imaging sterols in cells
CY Jao, D Nedelcu, LV Lopez, TN Samarakoon… - …, 2015 - Wiley Online Library
Cholesterol is a fundamental lipid component of eukaryotic membranes and a precursor of
potent signaling molecules, such as oxysterols and steroid hormones. Cholesterol and …
potent signaling molecules, such as oxysterols and steroid hormones. Cholesterol and …